Integrin αM/CD11b Antibody (2B2.38): sc-71444

Integrin αM Antibody (2B2.38) is a mouse monoclonal IgG1 kappa light chain antibody specifically designed to target Integrin αM, also known as CD11b, complement component receptor-3 α (CR3α), ITGAM, and Mac-1 α subunit. Located on the cell surface, Integrin αM is a crucial cell adhesion molecule that facilitates interactions with extracellular matrix proteins and other cells, playing a vital role in immune cell trafficking and response. Structurally, Integrin αM forms a heterodimer with Integrin β2, creating the Mac-1 or CR3 complex, which is essential for binding ligands like intracellular adhesion molecules (ICAMs) and enabling functions such as migration and phagocytosis. Anti-Integrin αM antibody (2B2.38) is raised against the I domain of human Integrin αM. Integrin αM′s location on the cell surface allows immune cells like neutrophils and monocytes to adhere to and migrate through the endothelium to sites of inflammation, as well as to engage in the phagocytosis of complement-coated pathogens. This structural configuration and cellular localization make Integrin αM a key player in the immune response, influencing both the initiation and resolution of inflammation. Validated for use in immunofluorescence (IF) and flow cytometry (FCM), anti-Integrin αM antibody (2B2.38) is an essential tool for researchers studying immune cell functions, inflammatory mechanisms, and related pathologies. Anti-Integrin αM antibody (2B2.38) enables detailed investigation into the processes of immune cell adhesion, migration, and pathogen clearance, which are fundamental for developing therapeutic strategies for immune-related diseases.

The preferred Integrin αM/CD11b antibody is Integrin αM/CD11b Antibody (OX42): sc-53086.