Integrin αV/ITGAV/CD51 Antibody (P2W7): sc-9969

Integrin αV Antibody (P2W7) is a mouse monoclonal IgG1 kappa light chain antibody that specifically detects human Integrin alpha V, also known as ITGAV, integrin subunit alpha V, or CD51, by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Integrin alpha V is a transmembrane protein that heterodimerizes with multiple β subunits (β1, β3, β5, β6, and β8) to form receptors for extracellular matrix proteins such as vitronectin, fibronectin, and osteopontin, playing a crucial role in cell adhesion, migration, and signaling. Integrin αV (P2W7) monoclonal antibody is raised against the full-length Integrin αV protein of human origin and is available in both unconjugated and conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, allowing flexibility for various applications. Integrin αV monoclonal antibody (P2W7) can help elucidate the role of integrins in mediating cell-cell and cell-matrix interactions, as well as signal transduction pathways that influence cell growth, differentiation, migration, and apoptosis. Anti-Integrin αV antibody (P2W7) provides a valuable tool for researchers investigating the function and regulation of Integrin αV and its associated signaling pathways.

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Integrin αV/ITGAV/CD51 Antibody (P2W7) References:

1. beta1 integrins regulate keratinocyte adhesion and differentiation by distinct mechanisms.  |  Levy, L., et al. 2000. Mol Biol Cell. 11: 453-66. PMID: 10679006
2. Integrins: versatility, modulation, and signaling in cell adhesion.  |  Hynes, RO. 1992. Cell. 69: 11-25. PMID: 1555235
3. Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs.  |  Henderson, NC., et al. 2013. Nat Med. 19: 1617-24. PMID: 24216753
4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.  |  Kim, H., et al. 2018. Cell. 175: 1756-1768.e17. PMID: 30550785
5. Integrin αV Mediates the Effects of Irisin on Human Mature Adipocytes.  |  Fu, T., et al. 2022. Obes Facts. 15: 442-450. PMID: 35320805
6. Integrin Alpha v Beta 6 (αvβ6) and Its Implications in Cancer Treatment.  |  Brzozowska, E. and Deshmukh, S. 2022. Int J Mol Sci. 23: PMID: 36293202
7. A modest proposal: targeting αv integrin-mediated activation of latent TGFbeta as a novel therapeutic approach to treat scleroderma fibrosis.  |  Leask, A., et al. 2024. Expert Opin Investig Drugs. 33: 279-285. PMID: 38393748
8. Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens.  |  Horton, MA., et al. 1985. Cancer Res. 45: 5663-9. PMID: 4053038
9. Integrins and signal transduction pathways: the road taken.  |  Clark, EA. and Brugge, JS. 1995. Science. 268: 233-9. PMID: 7716514
10. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function.  |  Miyamoto, S., et al. 1995. Science. 267: 883-5. PMID: 7846531
11. Epithelial integrins.  |  Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
12. Cooperation between soluble factors and integrin-mediated cell anchorage in the control of cell growth and differentiation.  |  Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Integrin αV/ITGAV/CD51 Antibody (P2W7) has 73 citations in a variety of scientific publications.

Primary antibodies like Anti-Integrin αV/ITGAV/CD51 Antibody (P2W7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Integrin αV/ITGAV/CD51 Antibody (P2W7) Specifications

Alternate Product Name: Integrin αV

Product Clone Name: P2W7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Integrin αV

Epitope Species: human

Product Reactivity/Detection: Integrin αV

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 73 citations in various scientific publications

Available Conjugates/Forms for Integrin αV/ITGAV/CD51 Antibody (P2W7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Integrin αV/β3/CD51/CD61 antibody is Integrin αV/β3/CD51/CD61 Antibody (23C6): sc-7312.