Integrin αX/ITGAX/CD11c Antibody (HC1/1): sc-53998

Integrin αX Antibody (HC1/1) is a mouse monoclonal IgG1 antibody that detects Integrin αX in human samples through immunoprecipitation (IP) and flow cytometry (FCM) applications. Integrin αX is a type 1 transmembrane protein that plays a crucial role in the immune system by forming a leukocyte-specific integrin when combined with the β2 chain, known as the inactivated-C3b receptor 4 (CR4). Anti-Integrin αX antibody (HC1/1) recognizes a protein essential for mediating the adherence of neutrophils and monocytes to activated endothelial cells, as well as facilitating the phagocytosis of complement-coated particles, which is vital for an effective immune response. Abnormal expression of Integrin αX is notably associated with hairy cell leukemia, highlighting Integrin αX′s importance in cancer biology and the activation of proto-oncogenes such as Ras and JunD. Additionally, transcription of Integrin αX is influenced by various proteins and DNA elements, including Sp1, AP-1 family members, C/EBP, Oct-2, and PU.1, which underscores the complexity of regulation. Integrin αX is predominantly found on monocyte-derived dendritic cells, macrophages, and natural killer cells, and upon activation, dendritic cells, particularly those in the skin and mucosal tissues, can migrate to lymphoid organs to interact with T and B cells, thereby initiating and shaping the adaptive immune response. Integrin αX monoclonal antibody (HC1/1) serves as an invaluable tool for researchers studying immune cell interactions and the underlying mechanisms of immune-related diseases.

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Integrin αX/ITGAX/CD11c Antibody (HC1/1) References:

1. Integrin CD11c contributes to monocyte adhesion with CD11b in a differential manner and requires Src family kinase activity.  |  Georgakopoulos, T., et al. 2008. Mol Immunol. 45: 3671-81. PMID: 18541300
2. CD11c-Positive Dendritic Cells in Triple-negative Breast Cancer.  |  Lee, H., et al. 2018. In Vivo. 32: 1561-1569. PMID: 30348717
3. An Allosteric Shift in CD11c Affinity Activates a Proatherogenic State in Arrested Intermediate Monocytes.  |  Hernandez, AA., et al. 2020. J Immunol. 205: 2806-2820. PMID: 33055281
4. Inducible ablation of CD11c+ cells to determine their role in skin wound repair.  |  Li, Z., et al. 2021. Immunology. 163: 105-111. PMID: 33502012
5. Allergen induces CD11c+ dendritic cell autophagy to aggravate allergic rhinitis through promoting immune imbalance.  |  He, YQ., et al. 2022. Int Immunopharmacol. 106: 108611. PMID: 35158226
6. CD11c+ B Cells Participate in the Pathogenesis of Graves' Disease by Secreting Thyroid Autoantibodies and Cytokines.  |  Cao, Y., et al. 2022. Front Immunol. 13: 836347. PMID: 35386700
7. Lysosomal acid lipase, CSF1R, and PD-L1 determine functions of CD11c+ myeloid-derived suppressor cells.  |  Zhao, T., et al. 2022. JCI Insight. 7: PMID: 35917184
8. Protocol to visualize CD11c+ cells in atherosclerosis using LacZ reporter mice.  |  Sauter, M., et al. 2022. STAR Protoc. 3: 101645. PMID: 36042879
9. Loss of cAMP Signaling in CD11c Immune Cells Protects Against Diet-Induced Obesity.  |  Zeng, L., et al. 2023. Diabetes. 72: 1235-1250. PMID: 37257047
10. Identification of Sp1-binding sites in the CD11c (p150,95 alpha) and CD11a (LFA-1 alpha) integrin subunit promoters and their involvement in the tissue-specific expression of CD11c.  |  López-Rodríguez, C., et al. 1995. Eur J Immunol. 25: 3496-503. PMID: 8566043

The preferred Integrin αX/ITGAX/CD11c antibody is Integrin αX/ITGAX/CD11c Antibody (B-6): sc-46676.