Adducin α Antibody (C-4): sc-133078

Adducin α Antibody (C-4) is a mouse monoclonal IgG2a antibody that detects Adducin α in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Adducin α is a crucial cytoskeletal protein that plays a significant role in organizing the cortical actin cytoskeleton, essential for maintaining cell shape and structure. Adducin α (C-4) antibody helps researchers study this protein′s function in the renal tubule, where Adducin α influences sodium-pump activity, linking to blood pressure regulation and hypertension pathophysiology. Adducin α′s interactions with spectrin and actin underscore its role in dynamic cytoskeleton reorganization during cellular processes, including apoptosis. Expression patterns of Adducin α, alongside Adducin β and γ, reveal a ubiquitous presence across tissues, vital for understanding functional implications in normal physiology and disease states. Anti-Adducin α antibody (C-4) serves as an invaluable tool for investigating this protein′s roles in cellular dynamics and potential implications in hypertension and related disorders.

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Adducin α Antibody (C-4) References:

1. Genetic mapping of blood pressure quantitative trait loci in Milan hypertensive rats.  |  Zagato, L., et al. 2000. Hypertension. 36: 734-9. PMID: 11082136
2. Lack of association between Gly460Trp polymorphism of alpha-adducin gene and salt sensitivity of blood pressure in Polish hypertensives.  |  Ciechanowicz, A., et al. 2001. Kidney Blood Press Res. 24: 201-6. PMID: 11528213
3. Downstream signalling and specific inhibition of c-MET/HGF pathway in small cell lung cancer: implications for tumour invasion.  |  Ma, PC., et al. 2007. Br J Cancer. 97: 368-77. PMID: 17667909
4. Purification of a 92-kDa cytoplasmic protein tightly associated with the cell-cell adhesion molecule E-cadherin (uvomorulin). Characterization and extractability of the protein complex from the cell cytostructure.  |  McCrea, PD. and Gumbiner, BM. 1991. J Biol Chem. 266: 4514-20. PMID: 1999432
5. Adducin is required for desmosomal cohesion in keratinocytes.  |  Rötzer, V., et al. 2014. J Biol Chem. 289: 14925-40. PMID: 24711455
6. A Review of the Epidemiological Evidence for Adducin Family Gene Polymorphisms and Hypertension.  |  Zhang, JR., et al. 2019. Cardiol Res Pract. 2019: 7135604. PMID: 31275642
7. Increased expression of phosphorylated adducin in tumor cells.  |  Luo, C., et al. 2020. J Int Med Res. 48: 300060520910646. PMID: 32237935
8. A γ-adducin cleavage fragment induces neurite deficits and synaptic dysfunction in Alzheimer's disease.  |  Xiong, M., et al. 2021. Prog Neurobiol. 203: 102074. PMID: 33992672
9. The adducin saga: pleiotropic genomic targets for precision medicine in human hypertension-vascular, renal, and cognitive diseases.  |  Gonzalez-Fernandez, E., et al. 2022. Physiol Genomics. 54: 58-70. PMID: 34859687
10. Adducin Regulates Sarcomere Disassembly During Cardiomyocyte Mitosis.  |  Xiao, F., et al. 2024. Circulation. 150: 791-805. PMID: 38708635

The preferred Adducin α antibody is Adducin α Antibody (4D1): sc-33633.