1-800-457-3801

SCBT Portrait Logo
Seach Input

α-dystroglycan Antibody (2238E2D2): sc-65629

1.0(1)
Write a reviewAsk a question

Datasheets
  • α-dystroglycan Antibody (2238E2D2) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
  • raised against brain tissue homogenate, with epitope mapping to the glycosylation site of α-dystroglycan of bovine origin
  • recommended for detection of brain α-dystroglycan of mouse, rat, human, bovine and rabbit origin by WB; non cross-reactive with skeletal muscle α-dystroglycan
  • See α-dystroglycan (IIH6): sc-53987 for α-dystroglycan antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
  • m-IgG2b BP-HRP is the preferred secondary detection reagent for α-dystroglycan Antibody (2238E2D2) for WB applications. This reagent is now offered in a bundle with α-dystroglycan Antibody (2238E2D2) (see ordering information below).

    QUICK LINKS

    SEE ALSO...

    α-dystroglycan Antibody (2238E2D2) is a mouse monoclonal IgG2b antibody that detects α-dystroglycan in mouse, rat, human, bovine, and rabbit samples through western blotting (WB). α-dystroglycan is a crucial membrane-associated glycoprotein that plays a significant role in the formation of the dystrophin-associated protein complex, which is essential for maintaining the structural integrity of muscle cells. α-dystroglycan (2238E2D2) antibody targets a protein primarily located at the cell surface, where α-dystroglycan interacts with various extracellular matrix components, including laminins, Agrin, and Perlecan, facilitating the organization of these molecules into functional basement membranes. Proper localization and function of α-dystroglycan are vital for muscle development and repair, as well as for the clustering of nicotinic acetylcholine receptors at the neuromuscular junction, which is critical for effective synaptic transmission. α-dystroglycan monoclonal antibody (2238E2D2) enables researchers to gain insights into the molecular mechanisms underlying muscle diseases and other conditions associated with dystroglycan dysfunction, making this research tool invaluable for advancing our understanding of muscle biology and pathology.

    For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

    Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

    LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

    α-dystroglycan Antibody (2238E2D2) References:

    1. LARGE2 facilitates the maturation of alpha-dystroglycan more effectively than LARGE.  |  Fujimura, K., et al. 2005. Biochem Biophys Res Commun. 329: 1162-71. PMID: 15752776
    2. Reactive oxygen species deglycosilate glomerular alpha-dystroglycan.  |  Vogtländer, NP., et al. 2006. Kidney Int. 69: 1526-34. PMID: 16672922
    3. α-dystroglycan is a potential target of matrix metalloproteinase MMP-2.  |  Sbardella, D., et al. 2015. Matrix Biol. 41: 2-7. PMID: 25483986
    4. Alpha-dystroglycan binding peptide A2G80-modified stealth liposomes as a muscle-targeting carrier for Duchenne muscular dystrophy.  |  Sasaki, E., et al. 2021. J Control Release. 329: 1037-1045. PMID: 33080271
    5. High degree of conservation of the enzymes synthesizing the laminin-binding glycoepitope of α-dystroglycan.  |  Bigotti, MG. and Brancaccio, A. 2021. Open Biol. 11: 210104. PMID: 34582712
    6. TRAPPC11-related muscular dystrophy with hypoglycosylation of alpha-dystroglycan in skeletal muscle and brain.  |  Munot, P., et al. 2022. Neuropathol Appl Neurobiol. 48: e12771. PMID: 34648194
    7. Exploring the In situ pairing of human galectins toward synthetic O-mannosylated core M1 glycopeptides of α-dystroglycan.  |  Villones, LL., et al. 2022. Sci Rep. 12: 17800. PMID: 36274065
    8. Altering the Modular Architecture of Galectins Affects its Binding with Synthetic α-Dystroglycan O-Mannosylated Core M1 Glycoconjugates In situ.  |  Villones, LL., et al. 2023. Chembiochem. 24: e202200783. PMID: 36892311
    9. The alpha-dystroglycan-beta-dystroglycan complex. Membrane organization and relationship to an agrin receptor.  |  Deyst, KA., et al. 1995. J Biol Chem. 270: 25956-9. PMID: 7592785
    10. Non-muscle alpha-dystroglycan is involved in epithelial development.  |  Durbeej, M., et al. 1995. J Cell Biol. 130: 79-91. PMID: 7790379

    Ordering Information

    Product NameCatalog #UNITPriceQtyFAVORITES

    α-dystroglycan Antibody (2238E2D2)

    sc-65629
    200 µg/ml
    $316.00

    α-dystroglycan Antibody (2238E2D2): m-IgG2b BP-HRP Bundle

    sc-548444
    200 µg Ab; 10 µg BP
    $354.00