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α-dystroglycan Antibody (2238E2D2) is a mouse monoclonal IgG2b antibody that detects α-dystroglycan in mouse, rat, human, bovine, and rabbit samples through western blotting (WB). α-dystroglycan is a crucial membrane-associated glycoprotein that plays a significant role in the formation of the dystrophin-associated protein complex, which is essential for maintaining the structural integrity of muscle cells. α-dystroglycan (2238E2D2) antibody targets a protein primarily located at the cell surface, where α-dystroglycan interacts with various extracellular matrix components, including laminins, Agrin, and Perlecan, facilitating the organization of these molecules into functional basement membranes. Proper localization and function of α-dystroglycan are vital for muscle development and repair, as well as for the clustering of nicotinic acetylcholine receptors at the neuromuscular junction, which is critical for effective synaptic transmission. α-dystroglycan monoclonal antibody (2238E2D2) enables researchers to gain insights into the molecular mechanisms underlying muscle diseases and other conditions associated with dystroglycan dysfunction, making this research tool invaluable for advancing our understanding of muscle biology and pathology.
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Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α-dystroglycan Antibody (2238E2D2) | sc-65629 | 200 µg/ml | $316.00 | |||
α-dystroglycan Antibody (2238E2D2): m-IgG2b BP-HRP Bundle | sc-548444 | 200 µg Ab; 10 µg BP | $354.00 |