α-dystroglycan Antibody (IIH6C4): sc-73586
- α-dystroglycan Antibody (IIH6C4) is a mouse monoclonal IgM κ, cited in 4 publications, provided at 200 µg/ml
- raised against purified dystrophin-glycoprotein complex of rabbit origin
- recommended for detection of α-dystroglycan of mouse, rat, human and rabbit origin by WB and IP; also reactive with additional species, including canine
- See α-dystroglycan (IIH6): sc-53987 for α-dystroglycan antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for α-dystroglycan Antibody (IIH6C4). This work is in progress.
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α-dystroglycan Antibody (IIH6C4) is a mouse monoclonal IgM antibody that detects α-dystroglycan in mouse, rat, human, and rabbit samples through western blotting (WB) and immunoprecipitation (IP) applications. α-dystroglycan (IIH6C4) antibody recognizes a crucial membrane-associated glycoprotein that plays a significant role in the formation of the dystrophin-associated protein complex, which is essential for maintaining the structural integrity of muscle cells. α-dystroglycan is primarily located at the cell surface, where α-dystroglycan interacts with various extracellular matrix components, including laminins, Agrin, and Perlecan, facilitating the organization of these molecules into functional structures such as basement membranes. Proper localization and function of α-dystroglycan are vital for muscle development and repair, as well as for the clustering of nicotinic acetylcholine receptors at the neuromuscular junction, which is critical for effective neuromuscular transmission. Anti-α-dystroglycan antibody (IIH6C4) enables researchers to gain insights into the molecular mechanisms underlying muscle diseases and other conditions associated with dystroglycan dysfunction, making α-dystroglycan (IIH6C4) monoclonal antibody an invaluable tool for advancing our understanding of muscle biology and pathology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
α-dystroglycan Antibody (IIH6C4) References:
- Abnormalities in alpha-dystroglycan expression in MDC1C and LGMD2I muscular dystrophies. | Brown, SC., et al. 2004. Am J Pathol. 164: 727-37. PMID: 14742276
- Brain alpha-dystroglycan displays unique glycoepitopes and preferential binding to laminin-10/11. | McDearmon, EL., et al. 2006. FEBS Lett. 580: 3381-5. PMID: 16709410
- Dynamic regulation of alpha-dystroglycan in mouse placenta. | Santhanakrishnan, M., et al. 2008. Placenta. 29: 932-6. PMID: 18930541
- Identification of alpha-dystroglycan binding sequences in the laminin alpha2 chain LG4-5 module. | Suzuki, N., et al. 2010. Matrix Biol. 29: 143-51. PMID: 19800000
- Glycoproteomic characterization of recombinant mouse α-dystroglycan. | Harrison, R., et al. 2012. Glycobiology. 22: 662-75. PMID: 22241827
- Ribitol restores functionally glycosylated α-dystroglycan and improves muscle function in dystrophic FKRP-mutant mice. | Cataldi, MP., et al. 2018. Nat Commun. 9: 3448. PMID: 30150693
- Protective role for the N-terminal domain of α-dystroglycan in Influenza A virus proliferation. | de Greef, JC., et al. 2019. Proc Natl Acad Sci U S A. 116: 11396-11401. PMID: 31097590
- A new patient-derived iPSC model for dystroglycanopathies validates a compound that increases glycosylation of α-dystroglycan. | Kim, J., et al. 2019. EMBO Rep. 20: e47967. PMID: 31566294
- Establishment of a novel monoclonal antibody against truncated glycoforms of α-dystroglycan lacking matriglycans. | Yamasaki, F., et al. 2021. Biochem Biophys Res Commun. 579: 8-14. PMID: 34583196
- Compound Heterozygous FKTN Variants in a Patient with Dilated Cardiomyopathy Led to an Aberrant α-Dystroglycan Pattern. | Gaertner, A., et al. 2022. Int J Mol Sci. 23: PMID: 35743126
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
α-dystroglycan Antibody (IIH6C4) | sc-73586 | 200 µg/ml | $316.00 |