QUICK LINKS
SEE ALSO...
Daxx Antibody (H-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects Daxx protein of mouse, rat, and human origin through western blotting, immunoprecipitation, immunofluorescence, and enzyme-linked immunosorbent assay. Daxx (H-7) antibody is offered in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase, phycoerythrin, fluorescein isothiocyanate, and multiple Alexa Fluor® conjugates. Daxx plays a crucial role in the regulation of apoptosis, particularly in the context of the FAS-mediated apoptotic pathway. When the FAS receptor is activated by its ligand, activation triggers a cascade of events leading to programmed cell death, which is essential for maintaining immune system balance and tissue homeostasis. Daxx is a key player in this process, as Daxx interacts with the death domain of the FAS receptor, facilitating the activation of Jun N-terminal kinase (JNK) and promoting apoptosis. Notably, while Daxx does not possess a death domain, Daxx overexpression can enhance FAS-mediated apoptosis by activating the JNK pathway. This pathway operates alongside, yet distinctly from, the FAS-FADD-FLICE pathway, which is another critical route for apoptosis. The Daxx pathway is sensitive to the apoptotic inhibitor protein Bcl-2, highlighting unique regulatory mechanisms in cell death.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Daxx Antibody (H-7) | sc-8043 | 200 µg/ml | $316.00 | |||
Daxx Antibody (H-7): m-IgG Fc BP-HRP Bundle | sc-528211 | 200 µg Ab; 10 µg BP | $354.00 | |||
Daxx Antibody (H-7): m-IgGκ BP-HRP Bundle | sc-520534 | 200 µg Ab, 40 µg BP | $354.00 | |||
Daxx Antibody (H-7): m-IgG2a BP-HRP Bundle | sc-547048 | 200 µg Ab; 10 µg BP | $354.00 | |||
Daxx Antibody (H-7) AC | sc-8043 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Daxx Antibody (H-7) HRP | sc-8043 HRP | 200 µg/ml | $316.00 | |||
Daxx Antibody (H-7) FITC | sc-8043 FITC | 200 µg/ml | $330.00 | |||
Daxx Antibody (H-7) PE | sc-8043 PE | 200 µg/ml | $343.00 | |||
Daxx Antibody (H-7) Alexa Fluor® 488 | sc-8043 AF488 | 200 µg/ml | $357.00 | |||
Daxx Antibody (H-7) Alexa Fluor® 546 | sc-8043 AF546 | 200 µg/ml | $357.00 | |||
Daxx Antibody (H-7) Alexa Fluor® 594 | sc-8043 AF594 | 200 µg/ml | $357.00 | |||
Daxx Antibody (H-7) Alexa Fluor® 647 | sc-8043 AF647 | 200 µg/ml | $357.00 | |||
Daxx Antibody (H-7) Alexa Fluor® 680 | sc-8043 AF680 | 200 µg/ml | $357.00 | |||
Daxx Antibody (H-7) Alexa Fluor® 790 | sc-8043 AF790 | 200 µg/ml | $357.00 |