CIB Antibody (5A1H7E12): sc-65998
- CIB Antibody (5A1H7E12) is a mouse monoclonal IgG1 provided at 200 µg/ml
- raised against purified truncated recombinant CIB of human origin
- recommended for detection of CIB of human origin by WB, IP, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CIB Antibody (5A1H7E12). This work is in progress.
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CIB Antibody (5A1H7E12) is a mouse monoclonal IgG1 antibody that detects calcium- and integrin-binding protein (CIB) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. CIB plays a crucial role in cellular signaling and regulation, particularly in platelets where CIB interacts with integrin α2b/β3, the fibrinogen receptor essential for platelet aggregation and clot formation. The binding of CIB to the cytoplasmic domain of α2b is influenced by intracellular calcium levels, highlighting CIB′s importance in calcium-mediated signaling pathways. Additionally, CIB′s ability to translocate to the Triton X-100-insoluble cytoskeleton in aggregated platelets indicates CIB′s dynamic cellular localization, which is vital for function in platelet activation and stability. Furthermore, CIB interacts with DNA-PKcs, a key protein involved in DNA repair and lymphoid development, suggesting a role in maintaining genomic integrity. With significant homology to calcineurin B and calmodulin, CIB is ubiquitously expressed across various human tissues, making anti-CIB antibody (5A1H7E12) an essential tool for researchers studying platelet biology and related signaling pathways.
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CIB Antibody (5A1H7E12) References:
- Recent molecular advances in studies of the concentrative Na+-dependent nucleoside transporter (CNT) family: identification and characterization of novel human and mouse proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). | Ritzel, MW., et al. 2001. Mol Membr Biol. 18: 65-72. PMID: 11396613
- Association of CIB with GPIIb/IIIa during outside-in signaling is required for platelet spreading on fibrinogen. | Naik, UP. and Naik, MU. 2003. Blood. 102: 1355-62. PMID: 12714504
- Azoarcus sp. CIB, an anaerobic biodegrader of aromatic compounds shows an endophytic lifestyle. | Fernández, H., et al. 2014. PLoS One. 9: e110771. PMID: 25340341
- Optimized second-generation CRY2-CIB dimerizers and photoactivatable Cre recombinase. | Taslimi, A., et al. 2016. Nat Chem Biol. 12: 425-30. PMID: 27065233
- Mutant p53 as a guardian of the cancer cell. | Mantovani, F., et al. 2019. Cell Death Differ. 26: 199-212. PMID: 30538286
- Effects of Intervention Program Prev@cib on Traditional Bullying and Cyberbullying. | Ortega-Barón, J., et al. 2019. Int J Environ Res Public Health. 16: PMID: 30781758
- Predictors of gastrointestinal bleeding in adult ICU patients: a systematic review and meta-analysis. | Granholm, A., et al. 2019. Intensive Care Med. 45: 1347-1359. PMID: 31489445
- Genetic characterization of the cyclohexane carboxylate degradation pathway in the denitrifying bacterium Aromatoleum sp. CIB. | Sanz, D. and Díaz, E. 2022. Environ Microbiol. 24: 4987-5004. PMID: 35768954
- Enhancing tellurite and selenite bioconversions by overexpressing a methyltransferase from Aromatoleum sp. CIB. | Alonso-Fernandes, E., et al. 2023. Microb Biotechnol. 16: 915-930. PMID: 36366868
- Penazaphilones J-L, Three New Hydrophilic Azaphilone Pigments from Penicillium sclerotiorum cib-411 and Their Anti-Inflammatory Activity. | Zhang, X., et al. 2023. Molecules. 28: PMID: 37049911
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CIB Antibody (5A1H7E12) | sc-65998 | 200 µg/ml | $316.00 |