MAP-4 Antibody (A-3): sc-365011

MAP-4 Antibody (A-3) is a mouse monoclonal IgG1 antibody that detects MAP-4 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MAP-4 is a crucial microtubule-associated protein that plays a significant role in the assembly and stability of microtubules, which are essential components of the cytoskeletal network. MAP-4 (A-3) antibody influences the spatial organization of microtubules within cells, thereby facilitating various cellular processes, including intracellular transport and cell division. MAP-4 is primarily expressed in tissues such as the kidney, lung, liver, testis, and spleen, where anti-MAP-4 antibody (A-3) contributes to the formation of interphase microtubules and the dynamics of mitotic spindle fibers during cell division. The presence of MAP-4 in these tissues underscores its vital role in maintaining cellular structure and function, making MAP-4 (A-3) monoclonal antibody an invaluable tool for scientists studying microtubule dynamics and their implications in health and disease.

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MAP-4 Antibody (A-3) References:

1. DNA damage increases sensitivity to vinca alkaloids and decreases sensitivity to taxanes through p53-dependent repression of microtubule-associated protein 4.  |  Zhang, CC., et al. 1999. Cancer Res. 59: 3663-70. PMID: 10446979
2. Differences in the regulation of microtubule stability by the pro-rich region variants of microtubule-associated protein 4.  |  Hasan, MR., et al. 2006. FEBS Lett. 580: 3505-10. PMID: 16714020
3. A novel fusion of the MALT1 gene and the microtubule-associated protein 4 (MAP4) gene occurs in diffuse large B-cell lymphoma.  |  Murga Penas, EM., et al. 2006. Genes Chromosomes Cancer. 45: 863-73. PMID: 16804917
4. A model for microtubule-associated protein 4 structure. Domains defined by comparisons of human, mouse, and bovine sequences.  |  West, RR., et al. 1991. J Biol Chem. 266: 21886-96. PMID: 1718985
5. Functional analyses of the domain structure of microtubule-associated protein-4 (MAP-U).  |  Aizawa, H., et al. 1991. J Biol Chem. 266: 9841-6. PMID: 2033072
6. A novel isoform of MAP4 organises the paraxial microtubule array required for muscle cell differentiation.  |  Mogessie, B., et al. 2015. Elife. 4: e05697. PMID: 25898002
7. Development of MAP4 Kinase Inhibitors as Motor Neuron-Protecting Agents.  |  Bos, PH., et al. 2019. Cell Chem Biol. 26: 1703-1715.e37. PMID: 31676236
8. miR-103-3p Regulates the Differentiation and Autophagy of Myoblasts by Targeting MAP4.  |  Zhang, X., et al. 2023. Int J Mol Sci. 24: PMID: 36835542
9. Mitophagy associated self-degradation of phosphorylated MAP4 guarantees the migration and proliferation responses of keratinocytes to hypoxia.  |  Feng, Y., et al. 2023. Cell Death Discov. 9: 168. PMID: 37198170
10. Effects of three microtubule-associated proteins (MAP2, MAP4, and Tau) on microtubules' physical properties and neurite morphology.  |  Nishida, K., et al. 2023. Sci Rep. 13: 8870. PMID: 37258650

The preferred MAP-4 antibody is MAP-4 Antibody (G-10): sc-390286.