S-100 Antibody (S1-61): sc-53438
- S-100 Antibody (S1-61) is a mouse monoclonal IgG1 κ S-100 antibody, cited in 25 publications, provided at 200 µg/ml
- raised against S-100 protein protein of human origin
- S-100 Antibody (S1-61) is recommended for detection of S-100 of mouse, rat and human origin by WB, IP, IF and IHC(P)
- Anti-S-100 Antibody (S1-61) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of S-100 (S1-61): sc-53438.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for S-100 Antibody (S1-61) for WB and IHC(P) applications. These reagents are now offered in bundles with S-100 Antibody (S1-61) (see ordering information below).
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S-100 Antibody (S1-61) is a mouse monoclonal IgG1 kappa light chain antibody that detects S-100 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). S-100 (S1-61) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. S-100 protein, a member of the EF-hand type calcium-binding protein family, plays a crucial role in intracellular calcium signaling and is involved in various cellular processes, including cell growth, differentiation, and apoptosis. S-100 protein′s ability to bind calcium ions is essential for regulating these processes, making S-100 a significant player in both normal physiology and pathological conditions. S-100 proteins are predominantly expressed in neural tissues, but S-100 proteins are also found in various other tissues, including muscle and immune cells, where S-100 proteins are implicated in inflammatory responses and tissue repair. S-100 proteins′ presence in leydig cells and the testis suggests involvement in hormone production and spermatogenesis, highlighting S-100 proteins′ importance in reproductive health. Additionally, calgranulins, which are related to S-100 proteins, are expressed in macrophages and epithelial cells, further emphasizing S-100 proteins′ diverse roles in both the nervous system and immune response.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
S-100 Antibody (S1-61) References:
- Isolation of a rat S100 alpha cDNA and distribution of its mRNA in rat tissues. | Zimmer, DB., et al. 1991. Brain Res Bull. 27: 157-62. PMID: 1742602
- Calcium-binding proteins of the EF-type. | Heizmann, CW. 1988. J Cardiovasc Pharmacol. 12 Suppl 5: S30-7. PMID: 2469875
- Production of monoclonal antibodies directed against antigenic determinants common to the alpha- and beta-chain of bovine brain S-100 protein. | Vanstapel, MJ., et al. 1985. Lab Invest. 52: 232-8. PMID: 2578587
- Developmental and functional studies of parvalbumin and calbindin D28K in hypothalamic neurons grown in serum-free medium. | Pfyffer, GE., et al. 1987. J Neurochem. 49: 442-51. PMID: 3298546
- Developmental appearance of the Ca2+-binding proteins parvalbumin, calbindin D-28K, S-100 proteins and calmodulin during testicular development in the rat. | Kägi, U., et al. 1988. Cell Tissue Res. 252: 359-65. PMID: 3383215
- Increase of skeletal muscle relaxation speed by direct injection of parvalbumin cDNA. | Müntener, M., et al. 1995. Proc Natl Acad Sci U S A. 92: 6504-8. PMID: 7604022
- S100 protein expression in subpopulations of neurons of rat brain. | Rickmann, M. and Wolff, JR. 1995. Neuroscience. 67: 977-91. PMID: 7675218
- Retinoic acid regulates the expression of the calcium binding protein, calbindin-D28K. | Wang, YZ. and Christakos, S. 1995. Mol Endocrinol. 9: 1510-21. PMID: 8584029
- A novel calcium-binding protein in amniotic fluid, CAAF1: its molecular cloning and tissue distribution. | Hitomi, J., et al. 1996. J Cell Sci. 109 (Pt 4): 805-15. PMID: 8718672
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
S-100 Antibody (S1-61) | sc-53438 | 200 µg/ml | $316.00 | |||
S-100 Antibody (S1-61): m-IgG Fc BP-HRP Bundle | sc-526810 | 200 µg Ab; 10 µg BP | $354.00 | |||
S-100 Antibody (S1-61): m-IgG1 BP-HRP Bundle | sc-532183 | 200 µg Ab; 20 µg BP | $354.00 | |||
S-100 Antibody (S1-61) AC | sc-53438 AC | 500 µg/ml, 25% agarose | $416.00 | |||
S-100 Antibody (S1-61) HRP | sc-53438 HRP | 200 µg/ml | $316.00 | |||
S-100 Antibody (S1-61) FITC | sc-53438 FITC | 200 µg/ml | $330.00 | |||
S-100 Antibody (S1-61) PE | sc-53438 PE | 200 µg/ml | $343.00 | |||
S-100 Antibody (S1-61) Alexa Fluor® 488 | sc-53438 AF488 | 200 µg/ml | $357.00 | |||
S-100 Antibody (S1-61) Alexa Fluor® 546 | sc-53438 AF546 | 200 µg/ml | $357.00 | |||
S-100 Antibody (S1-61) Alexa Fluor® 594 | sc-53438 AF594 | 200 µg/ml | $357.00 | |||
S-100 Antibody (S1-61) Alexa Fluor® 647 | sc-53438 AF647 | 200 µg/ml | $357.00 | |||
S-100 Antibody (S1-61) Alexa Fluor® 680 | sc-53438 AF680 | 200 µg/ml | $357.00 | |||
S-100 Antibody (S1-61) Alexa Fluor® 790 | sc-53438 AF790 | 200 µg/ml | $357.00 |