S-100 α/β chain Antibody (B32.1): sc-58839

S-100 α/β chain Antibody (B32.1) is a mouse monoclonal IgG1 antibody that detects S-100 alpha/beta chain protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). S-100 α/β chain (B32.1) antibody is available as a non-conjugated format. S-100 protein plays a crucial role in various cellular processes, including cell cycle progression and differentiation regulation, which are vital for maintaining normal cellular function and tissue homeostasis. S-100 proteins are implicated in calcium-induced calcium release activation, microtubule assembly inhibition, and protein kinase C-mediated phosphorylation modulation, highlighting their importance in signal transduction pathways. The S-100 family consists of two subunits, S-100 α and S-100 β, which share approximately 60% sequence identity and can form three distinct dimeric combinations: two α chains, two β chains, or one of each. This versatility in structure allows S-100 proteins to interact with various cellular partners, influencing a range of physiological and pathological processes. S-100 is predominantly localized in astrocyte cytoplasm and nuclei, Schwann′s cells, and certain tumors, including ependymomas and astrogliomas, and is also found in benign naevi and malignant melanocytic tumors, as well as in Langerhans cells in the skin. S-100 α and β expression in diverse tissues, alongside other calcium-binding proteins like calbindin and parvalbumin, underscores their significance in both neural and non-neural contexts, making anti-S-100 α/β chain antibody (B32.1) an essential tool for researchers studying these critical pathways.

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S-100 α/β chain Antibody (B32.1) References:

1. [Pathophysiologic aspects of S-100beta protein: a new biological marker of brain pathology].  |  Beaudeux, J., et al. 1999. Ann Biol Clin (Paris). 57: 261-72. PMID: 10377476
2. Isolation of a rat S100 alpha cDNA and distribution of its mRNA in rat tissues.  |  Zimmer, DB., et al. 1991. Brain Res Bull. 27: 157-62. PMID: 1742602
3. Calcium-binding proteins of the EF-type.  |  Heizmann, CW. 1988. J Cardiovasc Pharmacol. 12 Suppl 5: S30-7. PMID: 2469875
4. Developmental and functional studies of parvalbumin and calbindin D28K in hypothalamic neurons grown in serum-free medium.  |  Pfyffer, GE., et al. 1987. J Neurochem. 49: 442-51. PMID: 3298546
5. Developmental appearance of the Ca2+-binding proteins parvalbumin, calbindin D-28K, S-100 proteins and calmodulin during testicular development in the rat.  |  Kägi, U., et al. 1988. Cell Tissue Res. 252: 359-65. PMID: 3383215
6. [Diagnosis of latent late infections following total hip replacement].  |  Albrecht, HU. and Saxer, U. 1978. Schweiz Med Wochenschr. 108: 1262-70. PMID: 675218
7. Increase of skeletal muscle relaxation speed by direct injection of parvalbumin cDNA.  |  Müntener, M., et al. 1995. Proc Natl Acad Sci U S A. 92: 6504-8. PMID: 7604022
8. Retinoic acid regulates the expression of the calcium binding protein, calbindin-D28K.  |  Wang, YZ. and Christakos, S. 1995. Mol Endocrinol. 9: 1510-21. PMID: 8584029
9. A novel calcium-binding protein in amniotic fluid, CAAF1: its molecular cloning and tissue distribution.  |  Hitomi, J., et al. 1996. J Cell Sci. 109 (Pt 4): 805-15. PMID: 8718672

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-S-100 α/β chain Antibody (B32.1) has 15 citations in a variety of scientific publications.

Primary antibodies like Anti-S-100 α/β chain Antibody (B32.1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

S-100 α/β chain Antibody (B32.1) Specifications

Alternate Product Name: S100 protein A1/B (S100A1/S100B)

Product Clone Name: B32.1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: S-100

Epitope Species: bovine

Product Reactivity/Detection: S-100 α and β chains

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: bovine, porcine, feline and monkey

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 15 citations in various scientific publications

Available Conjugates/Forms for S-100 α/β chain Antibody (B32.1): N/A