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Nibrin Antibody (1D7) is a mouse monoclonal IgG1 antibody that detects Nibrin in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP) applications. Nibrin plays a crucial role in DNA damage response, particularly in double-strand break repair, by forming a complex with Mre11 and Rad50, which maintains genomic stability. Nibrin is primarily located in the nucleus, where anti-Nibrin antibody (1D7) can detect participation in MRN complex formation, a key player in DNA damage detection and repair. Nibrin′s nuclear localization enables rapid response to DNA lesions, preventing mutation accumulation that could lead to cancer. Mutations in the Nibrin gene are associated with Nijmegen breakage syndrome, a condition characterized by immunodeficiency, growth retardation, and cancer predisposition, highlighting Nibrin′s critical role in maintaining cellular integrity. Nibrin (1D7) antibody serves as an invaluable tool for researchers studying DNA repair mechanisms and Nibrin′s implications in various diseases.
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Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nibrin Antibody (1D7) | sc-56166 | 50 µg/0.5 ml | $316.00 |