Rad51B Antibody (1E11/6): sc-53429

Rad51B Antibody (1E11/6) is a mouse monoclonal IgG1 kappa light chain antibody engineered to recognize Rad51B protein from human and hamster origins with exceptional precision in applications such as western blotting (WB) and immunoprecipitation (IP). Anti-Rad51B antibody (1E11/6) is raised against a his-tagged full-length human Rad51B protein, ensuring robust and specific binding to the target antigen. Rad51B, also called R51H2, mREC2, and Rad51l1, is a critical member of the Rad52 family, playing a pivotal role in the homologous recombination repair (HRR) of DNA double-strand breaks, a fundamental process for maintaining genomic stability and preventing mutations that can lead to cancerous transformations. Located primarily within the nucleus, Rad51B facilitates the search for homology and the pairing of DNA strands, which are essential steps in the accurate repair of DNA damage. Rad51B′s nuclear localization is crucial as Rad51B effectively interacts with other key proteins involved in DNA repair pathways, such as BRCA1 and BRCA2, thereby influencing their subcellular localization and enhancing the cellular response to DNA damage. This interaction is vital for the prevention of genomic instability, a hallmark of many cancers, making Rad51B an important biomarker and target for cancer research and therapeutic development. Rad51B (1E11/6) antibody is available in a non-conjugated form as well as various conjugated forms, providing versatile options for diverse experimental setups. Anti-Rad51B antibody (1E11/6) enables researchers to gain deeper insights into the mechanisms of DNA repair, the role of Rad51B in maintaining genomic integrity, and its implications in cancer development and treatment.

The preferred Rad51B antibody is Rad51B Antibody (1H3/13): sc-53430.