Cdk4 Antibody (DCS-31) is a mouse monoclonal IgG2a kappa light chain antibody specifically engineered to detect Cyclin-dependent kinase 4 (Cdk4), also known as CDC2-like kinase 4, in mouse, rat, and human samples. anti-Cdk4 antibody (DCS-31) recognizes the full-length human Cdk4 protein, making it suitable for applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Cdk4 is a pivotal kinase located primarily in the nucleus and cytoplasm, where it forms complexes with D-type cyclins to regulate the progression of the cell cycle from the G1 to the S phase. By phosphorylating key substrates like the retinoblastoma protein (Rb), Cdk4 controls essential transitions that drive cell division, underscoring its importance in cellular proliferation and cancer research. The activity of Cdk4 is finely tuned through interactions with cyclins, which enhance its kinase activity, and inhibitors such as p16, which suppress its function. Additionally, the activation of Cdk4-cyclin complexes involves phosphorylation by Cdk-activating proteins (CAK), highlighting the sophisticated regulatory mechanisms that ensure proper cell cycle progression. Cdk4 monoclonal antibody (DCS-31) is available in both non-conjugated form and a variety of conjugated formats, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, to accommodate diverse experimental needs. Cdk4 (DCS-31) antibody is an invaluable tool for researchers investigating cell cycle dynamics and related signaling pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cdk4 Antibody (DCS-31) | sc-56277 | 200 µg/ml | $316.00 | |||
Cdk4 Antibody (DCS-31): m-IgG Fc BP-HRP Bundle | sc-528616 | 200 µg Ab; 10 µg BP | $354.00 | |||
Cdk4 Antibody (DCS-31): m-IgGκ BP-HRP Bundle | sc-521037 | 200 µg Ab, 40 µg BP | $354.00 | |||
Cdk4 Antibody (DCS-31) AC | sc-56277 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Cdk4 Antibody (DCS-31) HRP | sc-56277 HRP | 200 µg/ml | $316.00 | |||
Cdk4 Antibody (DCS-31) FITC | sc-56277 FITC | 200 µg/ml | $330.00 | |||
Cdk4 Antibody (DCS-31) PE | sc-56277 PE | 200 µg/ml | $343.00 | |||
Cdk4 Antibody (DCS-31) Alexa Fluor® 488 | sc-56277 AF488 | 200 µg/ml | $357.00 | |||
Cdk4 Antibody (DCS-31) Alexa Fluor® 546 | sc-56277 AF546 | 200 µg/ml | $357.00 | |||
Cdk4 Antibody (DCS-31) Alexa Fluor® 594 | sc-56277 AF594 | 200 µg/ml | $357.00 | |||
Cdk4 Antibody (DCS-31) Alexa Fluor® 647 | sc-56277 AF647 | 200 µg/ml | $357.00 | |||
Cdk4 Antibody (DCS-31) Alexa Fluor® 680 | sc-56277 AF680 | 200 µg/ml | $357.00 | |||
Cdk4 Antibody (DCS-31) Alexa Fluor® 790 | sc-56277 AF790 | 200 µg/ml | $357.00 |