Cdk4 Antibody (0.N.199): sc-70832

Cdk4 Antibody (0.N.199) is a mouse monoclonal IgG1 kappa light chain antibody designed to detect Cyclin-dependent kinase 4 (Cdk4), also known as CDC2-like kinase 4, in mouse, rat, and human samples. Anti-Cdk4 antibody (0.N.199) targets the full-length recombinant human Cdk4 protein, making it ideal for applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Cdk4 is a critical serine/threonine kinase that plays a fundamental role in regulating the cell cycle, particularly the transition from the G1 phase to the S phase, by forming complexes with D-type cyclins. These complexes phosphorylate key substrates, including the retinoblastoma protein (Rb), which facilitates the progression of the cell cycle and promotes cellular proliferation. The function of Cdk4 is essential for normal cell growth and division, and dysregulation is often associated with various cancers, making Cdk4 a significant target for cancer research and therapeutic development. By interacting with cyclins, Cdk4 activity is modulated to ensure controlled cell cycle progression, while inhibitors such as p16 can downregulate Cdk4 activity to prevent uncontrolled cell division. Understanding Cdk4′s function provides insights into the mechanisms of cell proliferation and the potential for developing targeted cancer therapies. Available in both non-conjugated and various conjugated forms, including horseradish peroxidase (HRP) and fluorescent tags, Cdk4 (0.N.199) antibody offers versatility to meet diverse research needs.

The preferred Cdk4 antibody is Cdk4 Antibody (DCS-35): sc-23896.