p14ARF Antibody (DCS-241): sc-53640
- p14ARF Antibody (DCS-241) is a mouse monoclonal IgG1 κ, cited in 7 publications, provided at 200 µg/ml
- raised against recombinant p14 ARF of human origin
- p14ARF Antibody (DCS-241) is recommended for detection of p14 ARF of human origin by WB, IP and IF
- Anti-p14ARF Antibody (DCS-241) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of p14ARF (DCS-241): sc-53640.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for p14ARF Antibody (DCS-241) for WB applications. These reagents are now offered in bundles with p14ARF Antibody (DCS-241) (see ordering information below).
p14 ARF Antibody (DCS-241) is a mouse monoclonal IgG1 kappa light chain antibody that detects p14 ARF of human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). p14 ARF monoclonal antibody (DCS-241) is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. p14 ARF protein plays a crucial role in regulating the cell cycle by acting as a tumor suppressor, primarily through interaction with MDM2 protein. By binding to MDM2, p14 ARF prevents MDM2 from promoting p53 degradation, thereby stabilizing p53 levels and enhancing p53′s ability to induce cell cycle arrest and apoptosis in response to cellular stress. This interaction maintains genomic integrity and prevents tumorigenesis, as p53 is a key player in cellular response to DNA damage. p14 ARF′s ability to modulate MDM2 and p53 activity underscores p14 ARF′s importance in cancer biology and highlights p14 ARF′s potential as a therapeutic target.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p14ARF Antibody (DCS-241) | sc-53640 | 200 µg/ml | $316.00 | |||
p14ARF Antibody (DCS-241): m-IgG Fc BP-HRP Bundle | sc-526840 | 200 µg Ab; 10 µg BP | $354.00 | |||
p14ARF Antibody (DCS-241): m-IgG1 BP-HRP Bundle | sc-532213 | 200 µg Ab; 20 µg BP | $354.00 | |||
p14ARF Antibody (DCS-241) AC | sc-53640 AC | 500 µg/ml, 25% agarose | $416.00 | |||
p14ARF Antibody (DCS-241) HRP | sc-53640 HRP | 200 µg/ml | $316.00 | |||
p14ARF Antibody (DCS-241) FITC | sc-53640 FITC | 200 µg/ml | $330.00 | |||
p14ARF Antibody (DCS-241) PE | sc-53640 PE | 200 µg/ml | $343.00 | |||
p14ARF Antibody (DCS-241) Alexa Fluor® 488 | sc-53640 AF488 | 200 µg/ml | $357.00 | |||
p14ARF Antibody (DCS-241) Alexa Fluor® 546 | sc-53640 AF546 | 200 µg/ml | $357.00 | |||
p14ARF Antibody (DCS-241) Alexa Fluor® 594 | sc-53640 AF594 | 200 µg/ml | $357.00 | |||
p14ARF Antibody (DCS-241) Alexa Fluor® 647 | sc-53640 AF647 | 200 µg/ml | $357.00 | |||
p14ARF Antibody (DCS-241) Alexa Fluor® 680 | sc-53640 AF680 | 200 µg/ml | $357.00 | |||
p14ARF Antibody (DCS-241) Alexa Fluor® 790 | sc-53640 AF790 | 200 µg/ml | $357.00 |