Chk1 Antibody (2G11D5): sc-56288
- Chk1 Antibody (2G11D5) is a mouse monoclonal IgG1 κ, cited in 10 publications, provided at 200 µg/ml
- raised against Ni-NTA purified recombinant Chk1 of human origin
- recommended for detection of Chk1 of mouse, rat and human origin by WB and IP
- See Chk1 (G-4): sc-8408 for Chk1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Chk1 Antibody (2G11D5) for WB applications. This reagent is now offered in a bundle with Chk1 Antibody (2G11D5) (see ordering information below).
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Chk1 Antibody (2G11D5) is a mouse monoclonal IgG1 antibody that detects Chk1 in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Chk1 plays a critical role in maintaining genomic stability by acting as a key regulator in the G2 DNA damage checkpoint, where Chk1 phosphorylates Cdc25C in response to DNA damage. This phosphorylation event inhibits Cdc25C activity, effectively blocking the transition into mitosis and allowing the cell time to repair DNA damage before division. Chk1 dysfunction can lead to unchecked cell division and contribute to tumorigenesis. Chk1 has been shown to interact with various proteins involved in cell cycle regulation, including Wee1, further underscoring Chk1′s pivotal role in orchestrating the cellular response to DNA damage. Anti-Chk1 antibody (2G11D5) serves as an invaluable tool for researchers studying cancer biology and therapeutic interventions.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chk1 Antibody (2G11D5) | sc-56288 | 200 µg/ml | $316.00 | |||
Chk1 Antibody (2G11D5): m-IgG Fc BP-HRP Bundle | sc-551939 | 200 µg Ab; 10 µg BP | $354.00 |