cyclin A Antibody (E43.2): sc-53229

Cyclin A Antibody (E43.2) is a mouse monoclonal IgG2a antibody that detects cyclin A in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Cyclin A plays a pivotal role in the regulation of the eukaryotic cell cycle, particularly during the S phase, where cyclin A is crucial for the proper progression and timing of DNA replication. Anti-cyclin A antibody (E43.2) targets a protein primarily located in the nucleus, where cyclin A associates with cyclin-dependent kinase-2 (Cdk2) to form active complexes that drive the cell cycle forward. Precise regulation of cyclin A is essential, as dysregulation can lead to uncontrolled cell proliferation and has been implicated in various cancers. Cyclin A also interacts with other key regulatory proteins, including E1A, transcription factors DRTF1 and E2F, and the retinoblastoma protein, p110, highlighting cyclin A′s importance in cell cycle control and transcriptional regulation. Anti-cyclin A antibody (E43.2) serves as an invaluable tool for researchers studying cell cycle dynamics and the molecular mechanisms underlying cell proliferation and transformation.

The preferred cyclin A antibody is cyclin A Antibody (BF683): sc-239.