cyclin D3 Antibody (D-7): sc-6283
- cyclin D3 Antibody (D-7) is a mouse monoclonal IgG1 κ cyclin D3 antibody, cited in 97 publications, provided at 200 µg/ml
- raised against amino acids 1-292 representing full length cyclin D3 of human origin
- cyclin D3 Antibody (D-7) is recommended for detection of cyclin D3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-cyclin D3 Antibody (D-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to TRITC for IF, IHC(P) and FCM
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of cyclin D3 (D-7): sc-6283.
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for cyclin D3 Antibody (D-7) for WB and IHC(P) applications. These reagents are now offered in bundles with cyclin D3 Antibody (D-7) (see ordering information below).
Cyclin D3 Antibody (D-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects cyclin D3 of mouse, rat, and human origin through applications such as western blotting, immunoprecipitation, immunofluorescence, immunohistochemistry, and enzyme-linked immunosorbent assay. Cyclin D3 (D-7) antibody is offered in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase, phycoerythrin, fluorescein isothiocyanate, and multiple Alexa Fluor® conjugates. Cyclin D3 plays a pivotal role in cell cycle regulation, particularly during the G1 phase, where cyclin D3 is essential for the transition to the S phase. This transition is crucial for DNA replication and cell division, making cyclin D3 a key player in cellular proliferation and growth. Dysregulation of cyclin D3 has been implicated in various cancers, as cyclin D3 can lead to uncontrolled cell division. Cyclin D3 interaction with cyclin-dependent kinases (CDKs) facilitates the phosphorylation of target proteins, which is necessary for the progression of the cell cycle. Understanding cyclin D3 function and regulatory mechanisms is vital for developing therapeutic strategies against cancers characterized by aberrant cell cycle control.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
cyclin D3 Antibody (D-7) References:
- Cloning of a D-type cyclin from murine erythroleukemia cells. | Kiyokawa, H., et al. 1992. Proc Natl Acad Sci U S A. 89: 2444-7. PMID: 1372445
- Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene. | Motokura, T., et al. 1992. J Biol Chem. 267: 20412-5. PMID: 1383201
- Genomic organization, chromosomal localization, and independent expression of human cyclin D genes. | Inaba, T., et al. 1992. Genomics. 13: 565-74. PMID: 1386335
- Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins. | Xiong, Y., et al. 1992. Genomics. 13: 575-84. PMID: 1386336
- Growth-regulated expression of D-type cyclin genes in human diploid fibroblasts. | Won, KA., et al. 1992. Proc Natl Acad Sci U S A. 89: 9910-4. PMID: 1409718
- Human D-type cyclin. | Xiong, Y., et al. 1991. Cell. 65: 691-9. PMID: 1827756
- Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation. | Draetta, G. 1990. Trends Biochem Sci. 15: 378-83. PMID: 2147521
- Cyclin D3 compensates for the loss of cyclin D1 during ErbB2-induced mammary tumor initiation and progression. | Zhang, Q., et al. 2011. Cancer Res. 71: 7513-24. PMID: 22037875
- The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor. | Taniguchi, K., et al. 2015. Diabetologia. 58: 2056-63. PMID: 26055066
- Cyclin D3 deficiency inhibits skin tumor development, but does not affect normal keratinocyte proliferation. | Lee, SH., et al. 2017. Oncol Lett. 14: 2723-2734. PMID: 28927034
- Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. | Ewen, ME., et al. 1993. Cell. 73: 487-97. PMID: 8343202
- Physical interaction of the retinoblastoma protein with human D cyclins. | Dowdy, SF., et al. 1993. Cell. 73: 499-511. PMID: 8490963
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cyclin D3 Antibody (D-7) | sc-6283 | 200 µg/ml | $316.00 | |||
cyclin D3 Antibody (D-7): m-IgG Fc BP-HRP Bundle | sc-528167 | 200 µg Ab; 10 µg BP | $354.00 | |||
cyclin D3 Antibody (D-7): m-IgGκ BP-HRP Bundle | sc-520476 | 200 µg Ab, 40 µg BP | $354.00 | |||
cyclin D3 Antibody (D-7) AC | sc-6283 AC | 500 µg/ml, 25% agarose | $416.00 | |||
cyclin D3 Antibody (D-7) HRP | sc-6283 HRP | 200 µg/ml | $316.00 | |||
cyclin D3 Antibody (D-7) FITC | sc-6283 FITC | 200 µg/ml | $330.00 | |||
cyclin D3 Antibody (D-7) PE | sc-6283 PE | 200 µg/ml | $343.00 | |||
cyclin D3 Antibody (D-7) Alexa Fluor® 488 | sc-6283 AF488 | 200 µg/ml | $357.00 | |||
cyclin D3 Antibody (D-7) Alexa Fluor® 546 | sc-6283 AF546 | 200 µg/ml | $357.00 | |||
cyclin D3 Antibody (D-7) Alexa Fluor® 594 | sc-6283 AF594 | 200 µg/ml | $357.00 | |||
cyclin D3 Antibody (D-7) Alexa Fluor® 647 | sc-6283 AF647 | 200 µg/ml | $357.00 | |||
cyclin D3 Antibody (D-7) Alexa Fluor® 680 | sc-6283 AF680 | 200 µg/ml | $357.00 | |||
cyclin D3 Antibody (D-7) Alexa Fluor® 790 | sc-6283 AF790 | 200 µg/ml | $357.00 | |||
cyclin D3 Antibody (D-7) TRITC | sc-6283 TRITC | 200 µg/ml | $320.00 |