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Human MMP-1 Luminex Performance Assay

Catalog #: LMP901B Datasheet / COA / SDS

Discontinued Product

LMP901B has been discontinued and is replaced by LMPM901.

R&D Systems Luminex High Performance Panel
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Summary Product Datasheets Background

Human MMP-1 Luminex Performance Assay Summary

Assay Type bead-based multiplex assay for the Luminex® platform
Format 1 x 96-well microplate and antibody-coated beads
Analytes Detected Please see analyte list in assay customization tool below.
Performance Validation Luminex Assays are validated for use with cell culture supernatants, plasma and serum. All Luminex assays are tested for sensitivity, intra-assay precision, inter-assay precision and to ensure assay linearity for validated sample types. Antibody pairs are selected and tested to confirm the parallel detection of natural and recombinant standard protein and to ensure the accurate determination of target analytes within biological samples. Assays for each target analyte are screened against all target analytes to confirm low antibody cross-reactivity.

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Assays for the Luminex platform are offered as High Performance Assays or Assays. The Luminex High Performance Assays are fully validated panels with a focused selection of analytes. They are available in We Mix, You Mix, and Predetermined formats. The Luminex Assays allows for the maximum number of analytes in a multiplex and is supplied as a premixed kit. View a table comparing the features and benefits of these bead-based multiplex assays.

Background: MMP-1

The matrix metalloproteinases (MMPs) consist of 24 known human zinc proteases with essential roles in breaking down components of the extracellular matrix (ECM). Additional MMP substrates include cytokines, chemokines, growth factors and binding proteins, cell/cell adhesion molecules, and other proteinases. With a few exceptions, MMPs share common structural motifs including a pro-peptide domain, a catalytic domain, a hinge region, and a hemopexin-like domain. Synthesized as pro-enzymes, most MMPs are secreted before conversion to their active form. MMP activities are modulated on several levels including transcription, pro-enzyme activation, or by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). A subset of MMPs are associated with membranes and designated as membrane-type metalloproteinases (MT-MMP).

Long Name
Matrix Metalloproteinase 1
Entrez Gene IDs
4312 (Human); 83995 (Mouse)
Alternate Names
CLGmatrix metalloprotease 1; CLGN; EC 3.4.24; EC 3.4.24.7; Fibroblast collagenase; interstitial collagenase; matrix metallopeptidase 1 (interstitial collagenase); matrix metalloproteinase 1 (interstitial collagenase); Matrix metalloproteinase-1; MMP1; MMP-1

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Luminex® is a registered trademark of Luminex Corporation.

Citations for Human MMP-1 Luminex Performance Assay

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

30 Citations: Showing 1 - 10
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  1. Profiling drugs for rheumatoid arthritis that inhibit synovial fibroblast activation
    Nat. Chem. Biol., 2016-10-31;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
  2. Membrane Type 1 Matrix Metalloproteinase Regulates Monocyte Migration and Collagen Destruction in Tuberculosis.
    Authors: Sathyamoorthy T, Tezera L, Walker N, Brilha S, Saraiva L, Mauri F, Wilkinson R, Friedland J, Elkington P
    J Immunol, 2015-06-19;195(3):882-91.
    Species: Human
    Sample Types: Cell Culture Supernates
  3. Identification of neutrophil activation markers as novel surrogate markers of CF lung disease.
    Authors: Rath T, Zwaschka L, Hage L, Kugler M, Menendez K, Naehrlich L, Schulz R, Roderfeld M, Roeb E
    PLoS ONE, 2014-12-29;9(12):e115847.
    Species: Human
    Sample Types: Serum
  4. Circulating mediators of inflammation and immune activation in AIDS-related non-hodgkin lymphoma.
    Authors: Nolen B, Breen E, Bream J, Jenkins F, Kingsley L, Rinaldo C, Lokshin A
    PLoS ONE, 2014-06-12;9(6):e99144.
    Species: Human
    Sample Types: Serum
  5. Serum CA19-9, cathepsin D, and matrix metalloproteinase-7 as a diagnostic panel for pancreatic ductal adenocarcinoma.
    Proteomics, 2012-12-01;12(23):3590-7.
    Species: Human
    Sample Types: Serum
  6. Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment.
    Authors: Coussens A, Wilkinson R, Hanifa Y, Nikolayevskyy V, Elkington P, Islam K, Timms P, Venton T, Bothamley G, Packe G, Darmalingam M, Davidson R, Milburn H, Baker L, Barker R, Mein C, Bhaw-Rosun L, Nuamah R, Young D, Drobniewski F, Griffiths C, Martineau A
    Proc Natl Acad Sci U S A, 2012-09-04;109(38):15449-54.
    Species: Human
    Sample Types: Serum
  7. Preserved ex vivo inflammatory status in decidual cells from women with preterm labor and subclinical intrauterine infection.
    Authors: Castro-Leyva V, Espejel-Nunez A, Barroso G, Zaga-Clavellina V, Flores-Pliego A, Morales-Mendez I, Giono-Cerezo S, Walsh S, Estrada-Gutierrez G
    PLoS ONE, 2012-08-22;7(8):e43605.
    Species: Human
    Sample Types: Cell Culture Supernates
  8. Altered circulating levels of matrix metalloproteinases and inhibitors associated with elevated type 2 cytokines in lymphatic filarial disease.
    Authors: Anuradha R, George JP, Pavankumar N, Kumaraswami V, Nutman TB, Babu S
    PLoS Negl Trop Dis, 2012-06-05;6(6):e1681.
    Species: Human
    Sample Types: Platelet Poor Plasma
  9. Establishment and detailed functional and molecular genetic characterisation of a novel sacral chordoma cell line, MUG-Chor1.
    Authors: Rinner B, Froehlich EV, Buerger K
    Int. J. Oncol., 2011-10-14;40(2):443-51.
    Species: Human
    Sample Types: Cell Culture Supernates
  10. Influence of variations across the MMP-1 and -3 genes on the serum levels of MMP-1 and -3 and disease activity in rheumatoid arthritis.
    Authors: Chen Y, Nixon NB, Dawes PT
    Genes Immun., 2011-07-14;13(1):29-37.
    Species: Human
    Sample Types: Serum
  11. MMP-1 drives immunopathology in human tuberculosis and transgenic mice.
    Authors: Elkington P, Shiomi T, Breen R, Nuttall RK, Ugarte-Gil CA, Walker NF, Saraiva L, Pedersen B, Mauri F, Lipman M, Edwards DR, Robertson BD, D'Armiento J, Friedland JS
    J. Clin. Invest., 2011-04-25;121(5):1827-33.
    Species: Human
    Sample Types: Sputum
  12. Circulating matrix metalloproteinases in infective endocarditis: a possible marker of the embolic risk.
    Authors: Thuny F, Habib G, Le Dolley Y, Canault M, Casalta JP, Verdier M, Avierinos JF, Raoult D, Mege JL, Morange PE, Alessi MC
    PLoS ONE, 2011-04-14;6(4):e18830.
    Species: Human
    Sample Types: Serum
  13. Development of a multimarker assay for early detection of ovarian cancer.
    Authors: Yurkovetsky Z, Skates S, Lomakin A, Nolen B, Pulsipher T, Modugno F, Marks J, Godwin A, Gorelik E, Jacobs I, Menon U, Lu K, Badgwell D, Bast RC, Lokshin AE
    J. Clin. Oncol., 2010-04-05;28(13):2159-66.
    Species: Human
    Sample Types: Serum
  14. Systemic Th17-like cytokine pattern in gangrenous appendicitis but not in phlegmonous appendicitis.
    Authors: Ruber M, Andersson M, Petersson BF, Olaison G, Andersson RE, Ekerfelt C
    Surgery, 2009-11-05;147(3):366-72.
    Species: Human
    Sample Types: Serum
  15. Serum matrix metalloproteinases in adult CF patients: Relation to pulmonary exacerbation.
    Authors: Roderfeld M, Rath T, Schulz R, Seeger W, Tschuschner A, Graf J, Roeb E
    J. Cyst. Fibros., 2009-07-14;8(5):338-47.
    Species: Human
    Sample Types: Serum
  16. Mast cell-dependent contraction of human airway smooth muscle cell-containing collagen gels: influence of cytokines, matrix metalloproteases, and serine proteases.
    Authors: Margulis A, Nocka KH, Brennan AM, Deng B, Fleming M, Goldman SJ, Kasaian MT
    J. Immunol., 2009-07-10;183(3):1739-50.
    Species: Human
    Sample Types: Cell Culture Supernates
  17. Characterization and peripheral blood biomarker assessment of anti-Jo-1 antibody-positive interstitial lung disease.
    Authors: Richards TJ, Eggebeen A, Gibson K, Yousem S, Fuhrman C, Gochuico BR, Fertig N, Oddis CV, Kaminski N, Rosas IO, Ascherman DP
    Arthritis Rheum., 2009-07-01;60(7):2183-92.
    Species: Human
    Sample Types: Serum
  18. Salbutamol up-regulates matrix metalloproteinase-9 in the alveolar space in the acute respiratory distress syndrome.
    Authors: O'Kane CM, McKeown SW, Perkins GD, Bassford CR, Gao F, Thickett DR, McAuley DF
    Crit. Care Med., 2009-07-01;37(7):2242-9.
    Species: Human
    Sample Types: BALF
  19. Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers.
    Authors: Shyamsundar M, McKeown ST, O'Kane CM, O'Kane CM, O'Kane CM, O'Kane CM, O'Kane CM, Craig TR, Brown V, Thickett DR, Matthay MA, Taggart CC, Backman JT, Elborn JS, McAuley DF
    Am. J. Respir. Crit. Care Med., 2009-03-26;179(12):1107-14.
    Species: Human
    Sample Types: BALF
  20. MMP dependence of fibroblast contraction and collagen production induced by human mast cell activation in a three-dimensional collagen lattice.
    Authors: Margulis A, Nocka KH, Wood NL, Wolf SF, Goldman SJ, Kasaian MT
    Am. J. Physiol. Lung Cell Mol. Physiol., 2008-12-05;296(2):L236-47.
    Species: Human
    Sample Types: Cell Culture Supernates
  21. MMP expression and abnormal lung permeability are important determinants of outcome in IPF.
    Authors: McKeown S, Richter AG, O'Kane C, O'Kane C, McAuley DF, Thickett DR
    Eur. Respir. J., 2008-10-01;33(1):77-84.
    Species: Human
    Sample Types: BALF
  22. Ultraviolet radiation and the role of matrix metalloproteinases in the pathogenesis of ocular surface squamous neoplasia.
    Authors: Ng J, Coroneo MT, Wakefield D, Di Girolamo N
    Invest. Ophthalmol. Vis. Sci., 2008-07-18;49(12):5295-306.
    Species: Human
    Sample Types: Cell Culture Supernates
  23. Epidermal growth factor-induced enhancement of glioblastoma cell migration in 3D arises from an intrinsic increase in speed but an extrinsic matrix- and proteolysis-dependent increase in persistence.
    Authors: Kim HD, Guo TW, Wu AP, Wells A, Gertler FB, Lauffenburger DA
    Mol. Biol. Cell, 2008-07-16;19(10):4249-59.
    Species: Human
    Sample Types: Cell Culture Supernates
  24. Serum samples are inappropriate for use in measuring circulating matrix metalloproteinases: comment on the article by Young-Min et al.
    Arthritis Rheum., 2008-05-01;58(5):1557-8; autho.
    Species: Human
    Sample Types: Serum
  25. MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis.
    Authors: Rosas IO, Richards TJ, Konishi K, Zhang Y, Gibson K, Lokshin AE, Lindell KO, Cisneros J, Macdonald SD, Pardo A, Sciurba F, Dauber J, Selman M, Gochuico BR, Kaminski N
    PLoS Med., 2008-04-29;5(4):e93.
    Species: Human
    Sample Types: Serum
  26. High levels and inflammatory effects of soluble CXC ligand 16 (CXCL16) in coronary artery disease: down-regulatory effects of statins.
    Authors: Smith C, Halvorsen B, Otterdal K, Waehre T, Yndestad A, Fevang B, Sandberg WJ, Breland UM, Froland SS, Oie E, Gullestad L, Damas JK, Aukrust P
    Cardiovasc. Res., 2008-03-13;79(1):195-203.
    Species: Human
    Sample Types: Cell Culture Supernates
  27. A potential role of the CXC chemokine GROalpha in atherosclerosis and plaque destabilization: downregulatory effects of statins.
    Authors: Breland UM, Halvorsen B, Hol J, ØIe E, Paulsson-Berne G, Yndestad A, Smith C, Otterdal K, Hedin U, Waehre T, Sandberg WJ, Froland SS, Haraldsen G, Gullestad L, Damas JK, Hansson GK, Aukrust P
    Arterioscler. Thromb. Vasc. Biol., 2008-02-14;28(5):1005-11.
    Species: Human
    Sample Types: Cell Culture Supernates
  28. Does MMP-12 Play a Role in Human Lung Fibrosis?
    Authors: Thickett DR, Perkins GD, O'Kane C, McKeown S, McAuley D
    2008-02-01;38(2):247.
    Species: Human
    Sample Types: BALF
  29. Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood.
    Authors: Hall JP, Kurdi Y, Hsu S, Cuozzo J, Liu J, Telliez JB, Seidl KJ, Winkler A, Hu Y, Green N, Askew GR, Tam S, Clark JD, Lin LL
    J. Biol. Chem., 2007-09-11;282(46):33295-304.
    Species: Human
    Sample Types: Cell Culture Supernates
  30. Salivary proteinase activity: a potential biomarker for preterm premature rupture of the membranes.
    Authors: Menon R, McIntyre JO, Matrisian LM, Fortunato SJ
    Am. J. Obstet. Gynecol., 2006-06-01;194(6):1609-15; disc.
    Species: Human
    Sample Types: Saliva

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