HLA-G (h2): 293T Lysate: sc-159524

The HLA-G (h2): 293T Lysate is derived from the HEK293T cell line, a human embryonic kidney cell line favored in research for its high transfection efficiency and robust protein expression. This lysate contains Human Leukocyte Antigen G (HLA-G), a non-classical major histocompatibility complex (MHC) class I molecule known for its role in immune tolerance. HLA-G is expressed in various tissues, including the placenta, where it helps to protect the fetus from maternal immune responses. Mechanistically, HLA-G interacts with inhibitory receptors on immune cells, such as ILT2 and ILT4, leading to the suppression of immune cell activation and cytotoxicity. In research, the HLA-G (h2): 293T Lysate is utilized to study the mechanisms of immune regulation and tolerance. Researchers employ this lysate in in vitro assays to investigate the interactions between HLA-G and its receptors, analyze the signaling pathways involved in immune suppression, and explore the regulatory factors controlling HLA-G expression. This lysate is particularly valuable for examining the role of HLA-G in modulating immune responses, as well as its impact on various cellular processes such as cytokine production and cell proliferation. Additionally, it aids in screening for potential modulators of HLA-G activity, providing insights into the complex dynamics of immune regulation and tolerance mechanisms.