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The Gelsolin (h2): 293T Lysate is derived from the HEK293T cell line, a human embryonic kidney cell line well-known for its high transfection efficiency and extensive use in molecular biology research. This lysate contains Gelsolin, an actin-binding protein that plays a critical role in the remodeling and regulation of the actin cytoskeleton. Gelsolin functions by severing actin filaments and capping their fast-growing ends, which regulates actin filament length and turnover. This activity is calcium-dependent, making Gelsolin a key player in processes that require rapid cytoskeletal rearrangement, such as cell motility, apoptosis, and signal transduction. In research, the Gelsolin (h2): 293T Lysate is used to investigate the molecular mechanisms underlying actin dynamics and cytoskeletal organization. Researchers utilize this lysate in in vitro assays to study the interactions between Gelsolin and actin, examine the effects of calcium on Gelsolin activity, and explore the regulatory pathways that control Gelsolin expression and function. This lysate is particularly valuable for analyzing the role of Gelsolin in cellular processes such as migration, shape changes, and mechanotransduction. Additionally, it aids in screening for potential modulators of Gelsolin activity, providing insights into how alterations in actin remodeling can impact cellular behavior. By leveraging this lysate, scientists gain a deeper understanding of the complex dynamics of the actin cytoskeleton and its broader implications in cell biology.
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gelsolin (h2): 293T Lysate | sc-171065 | 100 µg/200 µl | $232.00 |