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> home > Products > Peptides > Blocking Peptides > PKA C-beta (PRKACB) Antibody (N-term) Blocking peptide
PKA C-beta (PRKACB) Antibody (N-term) Blocking peptide
Synthetic peptide
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| Primary Accession | P22694 |
|---|---|
| Clone Names | 3031708 |
| Gene ID | 5567 |
|---|---|
| Other Names | cAMP-dependent protein kinase catalytic subunit beta, PKA C-beta, PRKACB |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7047a was selected from the N-term region of human PRKACB . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PRKACB |
|---|---|
| Function | Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs (PubMed:12420224, PubMed:21423175, PubMed:31112131). PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux (PubMed:12420224, PubMed:21423175). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175). Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed:21880142). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131). |
| Cellular Location | Cytoplasm. Cell membrane. Membrane; Lipid- anchor. Nucleus {ECO:0000250|UniProtKB:P05131} Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm {ECO:0000250|UniProtKB:P05131} |
| Tissue Location | Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain. |
Research Areas
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$ 277.78
Cat# BP7047a
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