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Recombinant Human Neuregulin-1/NRG1 Protein

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Summary
Product Discontinued
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    • Catalog Number
      H00003084-P01
    • Availability
      Product Discontinued

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Recombinant Human Neuregulin-1/NRG1 Protein Summary

Description
A recombinant protein with GST tag at N-terminal corresponding to the amino acids 1-241 of Human NRG1 full-length ORF

Source: Wheat Germ (in vitro)

Amino Acid Sequence:MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPQLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYSTSTPFLSLPE
Protein/Peptide Type
Recombinant Protein
Gene
NRG1

Applications/Dilutions

Dilutions
  • ELISA
  • Immunoaffinity Purification
  • Protein Array
  • SDS-Page
  • Western Blot
Application Notes
Western blot, ELISA. This protein has not been tested for any functionality. This product may contain endotoxins and is not suitable for use with live cells. This protein is not active and should not be used for experiments requiring activity.
Publications
Read Publication using
H00003084-P01 in the following applications:

  • PA
    1 publication

Packaging, Storage & Formulations

Storage
Store at -80C. Avoid freeze-thaw cycles.

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Recombinant Human Neuregulin-1/NRG1 Protein

  • ARIA
  • GGF2
  • GGFglial growth factor
  • Heregulin-1
  • HGL
  • HGLneu differentiation factor
  • HRG
  • HRG1
  • HRG1-alpha
  • HRG1-beta 1
  • HRGAneuregulin 1 type IV beta 1a
  • MST131
  • MSTP131
  • NDFheregulin, alpha (45kD, ERBB2 p185-activator)
  • neuregulin 1 type IV beta 3
  • neuregulin 1
  • Neuregulin1
  • Neuregulin-1
  • NRG1
  • pro-neuregulin-1, membrane-bound isoform
  • pro-NRG1
  • sensory and motor neuron derived factor
  • SMDF

Background

Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Recombinant Human
Neuregulin-1/NRG1 Pro ...
H00003084-P01
Recombinant Human Neuregulin-1/NRG1 Protein
Species: Hu
Applications: WB, ELISA, MA, PAGE, AP

Publications for Neuregulin-1/NRG1 Recombinant Protein (H00003084-P01)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: PA.


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Bioinformatics

Gene Symbol NRG1