Recombinant Human EMAP-II/AIMP1 Protein

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      P3601
    • Availability
      Product Discontinued

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Recombinant Human EMAP-II/AIMP1 Protein Summary

Description
A full-length recombinant protein corresponding to the amino acids 1 - 312 of Human SCYE1

Source: Escherichia coli

Amino Acid Sequence:MANNDAVLKRLEQKGAEADQIIEYLKQQVSLLKEKAILQATLREEKKLRVENAKLKKEIEELKQELIQAEIQNGVKQIPFPSGTPLHANSMVSENVIQSTAVTTVSSGTKEQIKGGTGDEKKAKEKIEKKGEKKEKKQQSIAGSADSKPIDVSRLDLRIGCIITARKHPDADSLYVEEVDVGEIAPRTVVSGLVNHVPLEQMQNRMVILLCNLKPAKMRGVLSQAMVMCASSPEKIEILAPPNGSVPGDRITFDAFPGEPDKELNPKKKIWEQIQPDLHTNDECVATYKGVPFEVKGKGVCRAQTMSNSGIK

Details of Functionality
This protein was produced in an in vitro wheat germ expression system that should preserve correct conformational folding that is necessary for biological function. While it is possible that this protein could display some level of activity, the functionality of this protein has not been explicitly measured or validated.
Source
E. coli
Protein/Peptide Type
Recombinant Protein
Gene
AIMP1
Purity
>90%, by SDS-PAGE
Endotoxin Note
< 0.1 ng/ug (1 EU/ug)

Applications/Dilutions

Dilutions
  • Bioactivity
  • Functional
  • SDS-Page
Theoretical MW
18 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at -20 to -70C as supplied. After reconstitution, store at 2 to 8C for 1 month and at -20 to -70C for long term storage. Avoid repeated freeze-thaw cycles.
Buffer
Lyophilized from 20 mM PB, 130 mM NaCl, pH 7.5
Preservative
No Preservative
Concentration
LYOPH
Purity
>90%, by SDS-PAGE
Reconstitution Instructions
Reconstitute with deionized water.

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Recombinant Human EMAP-II/AIMP1 Protein

  • AIMP1
  • aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
  • EMAP-2
  • EMAPII
  • EMAP-II
  • EMAPIImember 1 (endothelialmonocyte-activating)
  • endothelial-monocyte activating polypeptide II
  • Multisynthase complex auxiliary component p43
  • multisynthetase complex auxiliary component p43
  • SCYE1

Background

EMAP II (Endothelial-Monocyte-Activating Polypeptide II) is a proinflammatory cytokine and chemoattractant of macrophages and polymorphonuclear lymphocytes. EMAP II is synthesized as a 34 kDa precursor molecule which is cleaved to a biologically active 22 kDa mature polypeptide. This active protein is known to induce the procoagulant protein tissue factor on the surface of endothelial cells and modulate other properties of endothelial cells and monocytes in vitro, including the stimulation of TNF-alpha and myeloperoxidase. EMAP II activates neutrophils in vivo and induces an inflammatory reaction and tumor regression. EMAP II induces apoptosis in proliferating endothelial cells and inhibits neovascularization. This anti-angiogenic property is of interest to tumor biology. EMAP II is also a negative modulator of lung vascular growth.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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FAQs for EMAP-II/AIMP1 Recombinant Protein (P3601). (Showing 1 - 1 of 1 FAQ).

  1. Do you know if this protein is also functional for mouse cells?
    • The AIMP1 protein, P3601, is a human AIMP1 (Q12904, 1 a.a. - 312 a.a.) full-length recombinant protein, expressed in Escherichia coli. The protein has not been tested for functionality in mouse and we cannot therefore guarantee it.

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Bioinformatics

Gene Symbol AIMP1