Recombinant Mouse Leptin/OB Protein

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Summary
Product Discontinued
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    • Catalog Number
      P4527
    • Availability
      Product Discontinued

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Recombinant Mouse Leptin/OB Protein Summary

Description
Lep (Mouse) Recombinant Protein

Source: E. coli

Amino Acid Sequence:
Preparation
Method
Escherichia coli expression system
Details of Functionality
Determined in an in vivo assay using the ob/ob mouse obesity model and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5 mg leptin/gm of body weight for 7 days. Significant effects on body weight, food consumpt
Protein/Peptide Type
Recombinant Protein
Gene
LEP

Applications/Dilutions

Dilutions
  • Functional
  • SDS-Page
Application Notes
This product is useful for Func,SDS-PAGE.

Reactivity Notes

Mouse

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
No additive Reconstitute with 10 mM HCl.
Preservative
No Preservative

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Recombinant Mouse Leptin/OB Protein

  • FLJ94114
  • LEP
  • leptin (murine obesity homolog)
  • leptin (obesity homolog, mouse)
  • Leptin
  • OB
  • Obese protein
  • obese, mouse, homolog of
  • Obesity factor
  • OBOBS

Background

Leptin, the obese (ob) gene product, is a small protein expressed in and secreted from adipose tissue of normal rodents. Studies suggest leptin acts as a circulating hormone capable of regulating body-weight homeostasis and energy balance. One possible target tissue for leptin is the hypothalamus, a proposed control center for satiety and energy expenditure. Ob gene knockout mice are characterized by several metabolic abnormalities including hyperglucocorticoidemia, hyperinsulinemia and insulin resistance, hyperglycemia, altered central nervous system activity, reduced metabolic rate of brown adipose tissue, and a large increase in white adipose tissue. Studies show that the administration of recombinant leptin to ob knockout mice reduces food intake and increases energy expenditure.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol LEP