Recombinant Human Casein Kinase 2 alpha Protein

CK2alpha (also termed casein kinase IIalpha) is a serine-threonine protein kinase whose targets include many critical regulators of cellular growth. It is highly expressed in a lympho pro-liferative disease of cattle and in many human cancers. Overexpression of the CK2alpha catalytic subunit in lymphocytes of transgenic mice leads to T cell lymphoma (1). The highest CK2 activity is found in mouse testicles and brain, followed by spleen, liver, lung, kidney and heart (2). The activity values were directly correlated with the protein expression level of the CK2alpha (catalytic subunit). Thealpha subunit is only detected in brain and testicles. By contrast, Northern blot analyses of the CK2alpha mRNA shows the strongest signals to be present in brain, liver, heart and lung. In kidney, spleen and testicles mRNAs is only weakly detectable. ICBP90, a transcription factor exhibiting antiapoptotic property, has several putative CK2 phosphorylation sites. ICBP90 is more efficiently phosphorylated by the free CK2alpha subunit than by the heterotetrameric CK2 (a, Beta ) (3). Thus, CK2alpha is an important regulator of the transcriptional activity of ICBP90 and therefore of the antiapoptotic properties of ICBP90.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Array NBP1-99933

• Casein Kinase 2 alpha Antibodies
• Casein Kinase 2 alpha Lysate
• Casein Kinase 2 alpha Proteins
• Casein Kinase 2 alpha Proteins and Enzyme