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> home > Products > Peptides > Blocking Peptides > mouse Grin2a Antibody (Center K1081) Blocking peptide
mouse Grin2a Antibody (Center K1081) Blocking peptide
Synthetic peptide
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| Primary Accession | P35436 |
|---|---|
| Clone Names | 111205020 |
| Gene ID | 14811 |
|---|---|
| Other Names | Glutamate receptor ionotropic, NMDA 2A, GluN2A, Glutamate [NMDA] receptor subunit epsilon-1, N-methyl D-aspartate receptor subtype 2A, NMDAR2A, NR2A, Grin2a |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Grin2a {ECO:0000312|MGI:MGI:95820} |
|---|---|
| Function | Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:12008020, PubMed:1374164). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (PubMed:7816096, PubMed:8987814). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:12008020, PubMed:1374164, PubMed:7790891). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:10436042, PubMed:12008020). Participates in the synaptic plasticity regulation through activation by the L-glutamate releaseed by BEST1, into the synaptic cleft, upon F2R/PAR-1 activation in astrocyte (PubMed:25645137). |
| Cellular Location | Cell projection, dendritic spine. Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q12879}. Synapse. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q00959}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q12879}. Cytoplasmic vesicle membrane. Note=Expression at the dendrite cell membrane and at synapses is regulated by SORCS2 and the retromer complex. |
| Tissue Location | Detected in striatum (PubMed:28469074). Detected in forbrain (PubMed:7816096). Detected in cerebellum (at protein level) (PubMed:8987814). Detected in brain cortex, piriform cortex, hippocampus, caudate-putamen, dentate gyrus and granule cell layer (PubMed:1374164, PubMed:7816096). |
Research Areas
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$ 277.78
Cat# BP19357c
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