Grik3
| Gene Symbol | Grik3 |
|---|---|
| Entrez Gene | 14807 |
| Alt Symbol | 9630027E11, GluK3, GluR7-3, Glur-7, Glur7 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | glutamate receptor, ionotropic, kainate 3 |
| Other Description | glutamate receptor 7|glutamate receptor ionotropic, kainate 3 |
| Swissprots | B1AS29 Q9JIA8 Q17R20 |
| Accessions | B1AS29 AF245444 AAF90049 AK036014 BC118004 AAI18005 BC160379 AAI60379 BI133765 BM899529 BM933834 BM944246 BQ178996 BU611628 CD802840 CD804292 CF744155 CF745811 CJ149719 CX563583 XM_006502772 XP_006502835 NM_001081097 NP_001074566 |
| Function | Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Tissue Specificity | Detected in whole brain, cerebellum, brain cortex and hippocampus. {ECO:0000269|PubMed:11124978}. |
| Top Pathways | Glutamatergic synapse, Neuroactive ligand-receptor interaction |
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