| Gene Symbol |
BHLHE22
|
| Entrez Gene |
27319
|
| Alt Symbol |
BHLHB5, Beta3, CAGL85, TNRC20
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
basic helix-loop-helix family, member e22
|
| Other Description |
basic helix-loop-helix domain containing, class B, 5|class B basic helix-loop-helix protein 5|class E basic helix-loop-helix protein 22|trinucleotide repeat containing 20|trinucleotide repeat-containing gene 20 protein
|
| Swissprots |
Q8NFJ8
|
| Accessions |
AAM28881 EAW86876 Q8NFJ8 AA927689 AI867692 AI968349 AK091333 AK293979 BAG57349 AW206610 BC033056 BC045748 BC156671 AAI56672 BK000273 DAA01053 NM_152414 NP_689627
|
| Function |
Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Brain-specific, with the highest expression in the cerebellum. {ECO:0000269|PubMed:12213201}.
|