| Gene Symbol | Pvrl3 |
|---|---|
| Entrez Gene | 58998 |
| Alt Symbol | 2610301B19Rik, 3000002N23Rik, 4921513D19Rik, AA407785, AU016832, AW538082, CD113 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | poliovirus receptor-related 3 |
| Other Description | nectin-3|poliovirus receptor-related protein 3 |
| Swissprots | Q9JLB8 Q059N7 Q9JLB9 Q9JLB7 Q9D006 |
| Accessions | EDK98086 EDK98087 EDK98088 EDK98089 Q9JLB9 AF195833 AAF63685 AF195834 AAF63686 AF195835 AAF63687 AK004403 AK011949 BAB27933 AK012834 AK013863 AK085839 AK213929 BC125588 AAI25589 BC132187 AAI32188 BQ174425 BU701648 BY713810 CJ102084 XM_006522434 XP_006522497 XM_006522435 XP_006522498 XM_006522436 XP_006522499 XR_384582 XR_384583 NM_021495 NP_067470 NM_021496 NP_067471 NM_021497 NP_067472 |
| Function | Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. {ECO:0000269|PubMed:10744716, ECO:0000269|PubMed:11827984, ECO:0000269|PubMed:12121624, ECO:0000269|PubMed:12558799, ECO:0000269|PubMed:16128743}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000269|PubMed:11827984}. |
| Tissue Specificity | Ubiquitous with high expression in testes. Localized in spermatids at Sertoli-spermatid junctions. Expressed in ovarian granulosa cells, but only faintly expressed after ovulation. {ECO:0000269|PubMed:10744716, ECO:0000269|PubMed:12121624}. |
| Top Pathways | Adherens junction, Cell adhesion molecules (CAMs) |