Gene Symbol | CTSE |
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Entrez Gene | 1510 |
Alt Symbol | CATE |
Species | Human |
Gene Type | protein-coding |
Description | cathepsin E |
Other Description | erythrocyte membrane aspartic proteinase|slow-moving proteinase |
Swissprots | Q9UCE4 Q9NY58 Q5TZ01 P14091 Q5TZ02 Q9UCE3 |
Accessions | AAA52300 EAW91592 EAW91593 P14091 AJ250716 CAB82849 AJ250717 CAB82850 AK292057 BAF84746 AK298069 BAG60360 AU100136 BC042537 AAH42537 J05036 AAA52130 JF432419 ADZ15636 XM_011509244 XP_011507546 XM_011509245 XP_011507547 NM_001910 NP_001901 NM_148964 NP_683865 |
Function | May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain. {ECO:0000269|PubMed:8765029}. |
Subcellular Location | Endosome {ECO:0000269|PubMed:7983070}. Note=The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome. |
Tissue Specificity | Expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B- lymphocytes. {ECO:0000269|PubMed:11322887, ECO:0000269|PubMed:1370478, ECO:0000269|PubMed:8765029}. |
Top Pathways | Lysosome |
cathepsin E CRISPR/Cas9 KO Plasmid (h) - sc-403406 from Santa Cruz Biotechnology
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cathepsin E HDR Plasmid (h) - sc-403406-HDR from Santa Cruz Biotechnology
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cathepsin E Double Nickase Plasmid (h) - sc-403406-NIC from Santa Cruz Biotechnology
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cathepsin E Double Nickase Plasmid (h2) - sc-403406-NIC-2 from Santa Cruz Biotechnology
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cathepsin E CRISPR Activation Plasmid (h) - sc-403406-ACT from Santa Cruz Biotechnology
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cathepsin E CRISPR Activation Plasmid (h2) - sc-403406-ACT-2 from Santa Cruz Biotechnology
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cathepsin E Lentiviral Activation Particles (h) - sc-403406-LAC from Santa Cruz Biotechnology
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cathepsin E Lentiviral Activation Particles (h2) - sc-403406-LAC-2 from Santa Cruz Biotechnology
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cathepsin E siRNA (h) - sc-41473 from Santa Cruz Biotechnology
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cathepsin E shRNA Plasmid (h) - sc-41473-SH from Santa Cruz Biotechnology
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cathepsin E shRNA (h) Lentiviral Particles - sc-41473-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU158571 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6750 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6750 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07204 from Sigma-Aldrich
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CTSE siRNA (Human) - CRH1067 from Cohesion Biosciences
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CTSE - MBS8223371 from MyBioSource
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shRNA set against Human CTSE (NM_001910.3) - SHH271529 from Creative biogene
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Human CTSE siRNA - orb261569 from Biorbyt
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CTSE shRNA Plasmid (Human) - CHH1067 from Cohesion Biosciences
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CTSE miRNA 3'UTR clone - MiUTR3H-00378 from Creative biogene
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CTSE miRNA 3'UTR clone - MiUTR3H-00379 from Creative biogene
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