NEK4

Gene Symbol	NEK4
Entrez Gene	6787
Alt Symbol	NRK2, STK2, pp12301
Species	Human
Gene Type	protein-coding
Description	NIMA-related kinase 4
Other Description	NIMA (never in mitosis gene a)-related kinase 4|never in mitosis A-related kinase 4|nimA-related protein kinase 4|serine/threonine kinase 2|serine/threonine protein kinase-2|serine/threonine-protein kinase 2|serine/threonine-protein kinase NRK2|serine/threonine-protein kinase Nek4|serine/threonine-protein kinase Nek4 variant 2
Swissprots	Q6P576 P51957 B2R633 A5YM70 B7Z200
Accessions	EAW65258 P51957 AI860526 AK294165 BAH11686 AK312420 BAG35330 BC015515 AAH15515 BC063044 AAH63044 DB073127 EF560744 ABQ59054 KJ592714 AHZ86932 L20321 AAA36658 XM_006713310 XP_006713373 XM_011534039 XP_011532341 XM_011534040 XP_011532342 NM_001193533 NP_001180462 NM_003157 NP_003148
Function	Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}.
Subcellular Location	Cell projection, cilium {ECO:0000269|PubMed:21685204}. Cytoplasm {ECO:0000269|PubMed:21685204}.
Tissue Specificity	Highest expression in adult heart, followed by pancreas, skeletal muscle, brain, testis, retina, liver, kidney, lung and placenta. Present in most primary carcinomas. {ECO:0000269|PubMed:21685204, ECO:0000269|PubMed:8208544}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Nek4 CRISPR/Cas9 KO Plasmid (h) - sc-405220 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Nek4 HDR Plasmid (h) - sc-405220-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Nek4 Double Nickase Plasmid (h) - sc-405220-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Nek4 Double Nickase Plasmid (h2) - sc-405220-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Nek4 CRISPR Activation Plasmid (h) - sc-405220-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Nek4 CRISPR Activation Plasmid (h2) - sc-405220-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Nek4 Lentiviral Activation Particles (h) - sc-405220-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Nek4 Lentiviral Activation Particles (h2) - sc-405220-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Nek4 siRNA (h) - sc-106815 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Nek4 shRNA Plasmid (h) - sc-106815-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Nek4 shRNA (h) Lentiviral Particles - sc-106815-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

NEK4 RNAi - H00006787-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU136371 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1401 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1399 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1400 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN15201 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15201 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08271 from Sigma-Aldrich Category miRNA

NEK4 siRNA (Human) - CRH4643 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Nek4 CRISPR/Cas9 KO Plasmid (h2) - sc-405220-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Nek4 HDR Plasmid (h2) - sc-405220-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human NEK4 (NM_003157.4) - SHH351252 from Creative biogene Category siRNA Species Reactivities Human

Human NEK4 siRNA - orb265145 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

NEK4 shRNA Plasmid (Human) - CHH4643 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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