Gene Symbol | CYP2R1 |
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Entrez Gene | 120227 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | cytochrome P450, family 2, subfamily R, polypeptide 1 |
Other Description | cytochrome P450 2R1|cytochrome P450, family 2, R1|vitamin D 25-hydroxylase |
Swissprots | Q5RT65 Q6VVX0 Q2M3H3 |
Accessions | AAV65814 EAW68470 EAW68471 EAW68472 EAW68473 Q6VVX0 AK092584 AK312019 BAG34956 AW138676 AY323817 AAQ23114 BC052580 BC084557 BC104907 AAI04908 BC104909 AAI04910 BC111070 XM_005252788 XP_005252845 XM_005252789 XP_005252846 XM_005252791 XP_005252848 XM_006718142 XP_006718205 XM_011519894 XP_011518196 XM_011519895 XP_011518197 XM_011519896 XP_011518198 XM_011519897 XP_011518199 XM_011519898 XP_011518200 XR_242777 NM_024514 NP_078790 |
Function | Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3). {ECO:0000269|PubMed:12867411, ECO:0000269|PubMed:15465040, ECO:0000269|PubMed:18511070}. |
Subcellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
Top Pathways | Steroid biosynthesis |
CYP2R1 CRISPR/Cas9 KO Plasmid (h) - sc-404463 from Santa Cruz Biotechnology
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CYP2R1 HDR Plasmid (h) - sc-404463-HDR from Santa Cruz Biotechnology
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CYP2R1 Double Nickase Plasmid (h) - sc-404463-NIC from Santa Cruz Biotechnology
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CYP2R1 Double Nickase Plasmid (h2) - sc-404463-NIC-2 from Santa Cruz Biotechnology
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CYP2R1 CRISPR Activation Plasmid (h) - sc-404463-ACT from Santa Cruz Biotechnology
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CYP2R1 CRISPR Activation Plasmid (h2) - sc-404463-ACT-2 from Santa Cruz Biotechnology
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CYP2R1 Lentiviral Activation Particles (h) - sc-404463-LAC from Santa Cruz Biotechnology
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CYP2R1 Lentiviral Activation Particles (h2) - sc-404463-LAC-2 from Santa Cruz Biotechnology
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CYP2R1 siRNA (h) - sc-60481 from Santa Cruz Biotechnology
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CYP2R1 shRNA Plasmid (h) - sc-60481-SH from Santa Cruz Biotechnology
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CYP2R1 shRNA (h) Lentiviral Particles - sc-60481-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU122791 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6886 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6886 from Sigma-Aldrich
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CYP2R1 siRNA (Human) - CRJ4637 from Cohesion Biosciences
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CYP2R1 - MBS8234411 from MyBioSource
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shRNA set against Human CYP2R1 (NM_024514.4) - SHH273377 from Creative biogene
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shRNA set against Human CYP2R1(NM_024514.4) - SHG217279 from Creative biogene
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Human CYP2R1 siRNA - orb275138 from Biorbyt
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CYP2R1 shRNA Plasmid (Human) - CHJ4637 from Cohesion Biosciences
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CYP2R1 miRNA 3'UTR clone - MiUTR1H-02626 from Creative biogene
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