| Gene Symbol | HDAC1 |
|---|---|
| Entrez Gene | 404126 |
| Alt Symbol | - |
| Species | Bovine |
| Gene Type | protein-coding |
| Description | histone deacetylase 1 |
| Other Description | HD1 |
| Swissprots | Q32PJ8 |
| Accessions | DAA32275 Q32PJ8 AY504948 AAR98734 BC108088 AAI08089 BT030718 ABS45034 XM_005202895 XP_005202952 NM_001037444 NP_001032521 |
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A |
| Subcellular Location | Nucleus {ECO:0000250}. |
| Top Pathways | Viral carcinogenesis, Alcoholism, Epstein-Barr virus infection, Cell cycle, Huntington's disease |
Recombinant Bovine Histone deacetylase 1(HDAC1) - CSB-YP010235BO CSB-EP010235BO CSB-BP010235BO CSB-MP010235BO from Cusabio
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Histone deacetylase 1 (HDAC1), Recombinant Protein - MBS1297273 from MyBioSource
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