Numb

Gene Symbol Numb
Entrez Gene 18222
Alt Symbol Nb
Species Mouse
Gene Type protein-coding
Description numb gene homolog (Drosophila)
Other Description protein numb homolog
Swissprots Q9QZS3 Q9QZR1 Q9DC57 P70422 Q9QZS4 Q8CIB1
Accessions EDL02747 EDL02748 EDL02749 EDL02750 EDL02751 EDL02752 Q9QZS3 AF169191 AAD47834 AF169192 AAD47835 AF170709 AAD47836 AK004553 BAB23367 AK085841 AK164313 AK169548 BC033459 AAH33459 BC050108 AAH50108 BY129388 U70674 AAB09586 XM_006515572 XP_006515635 XM_006515573 XP_006515636 XM_006515574 XP_006515637 XM_006515575 XP_006515638 XM_006515576 XP_006515639 XM_006515577 XP_006515640 XM_006515578 XP_006515641 XM_011244012 XP_011242314 NM_001136075 NP_001129547 NM_001272055 NP_001258984 NM_001272056 NP_001258985 NM_010949 NP_035079 NR_073563 NR_073564
Function Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. {ECO:0000269|PubMed:10841580, ECO:0000269|PubMed:12410312, ECO:0000269|PubMed:15273690, ECO:0000269|PubMed:17174898}.
Subcellular Location Membrane; Peripheral membrane protein.
Tissue Specificity Expressed in subventricular zone (SVZ) neuroprogenitors and ependymal cells. {ECO:0000269|PubMed:17174898}.
Top Pathways Notch signaling pathway

Numb Antibody - NB500-178 from Novus Biologicals

Prices $99.00, $279.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: NUMB Antibody [NB500-178] - Detection of NUMB isoforms 1 and 2 in A431 whole cell lysate (20 ug) using 0.5 ug/ml of NB500-178. ECL detection: 30 seconds.

Numb Antibody - NBP1-98479 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Numb Antibody [NBP1-98479] - Mouse Brain Lysate 1.0ug/ml, Gel Concentration: 12%

Numb Antibody [DyLight 405] - NB500-178V from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Numb Antibody [FITC] - NB500-178F from Novus Biologicals

Prices $309.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Numb Antibody [Alexa Fluor (R) 700] - NB500-178AF700 from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal

Numb Antibody [Alexa Fluor (R) 647] - NB500-178AF647 from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal

Numb Antibody [Alexa Fluor (R) 488] - NB500-178AF488 from Novus Biologicals

Prices $329.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal

Numb Antibody [Alexa Fluor (R) 405] - NB500-178AF405 from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Rabbit
Clonality Polyclonal

Numb Antibody [DyLight 650] - NB500-178C from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Numb Antibody [Biotin] - NB500-178B from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Numb Antibody [HRP] - NB500-178H from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Numb Antibody [DyLight 488] - NB500-178G from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Numb Antibody [DyLight 550] - NB500-178R from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NUMB antibody produced in rabbit - SAB2107387 from Sigma-Aldrich

Prices $341.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-NUMB: <B>Cat. No. SAB2107387</B>: Western blot analysis of Numb in Mouse Brain with Numb (numb gene homolog, Drosophila) antibody, against the C terminal of Numb (50 μg) antibody at 1.0 μg/mL.

Numb antibody - C-terminal region (ARP59433_P050) - ARP59433_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Numb Homolog (Drosophila) Antibody - abx114253 from Abbexa

Host Rabbit
Clonality Polyclonal

NUMB antibody - PAB12086 from Acris Antibodies

Prices $500.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of Numb isoforms 1 and 2 in A-431 whole cell lysate ( 20 µg ) with Numb polyclonal antibody at 0.5 µg/ml ( Cat# PAB12086 ).

Anti-NUMB antibody - STJ70112 from St John's Laboratory Ltd

Host Goat
Clonality Polyclonal

Numb Antibody - GWB-MV602H from Genway Biotech

Prices $368.00
Sizes 50 µg
Host Rabbit

Anti-NUMB (aa 600-653) polyclonal antibody - DPAB-DC786 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-Numb Antibody - 07-147 from EMD Millipore

Host Rabbit
Clonality Polyclonal

Anti-Numb (pan-isoform) Antibody - 07-207 from EMD Millipore

Host Rabbit
Clonality Polyclonal
A431 cell lysate probed with anti-Numb, pan isoform (2μg/ml). Arrows indicates the various Numb isoforms.

Anti-Numb p72/p71 Antibody - 07-144 from EMD Millipore

Host Rabbit
Clonality Polyclonal

Cmnb-1 - Cmnb-1 from Developmental Studies Hybridoma Bank

Host Mouse
Clonality Monoclonal
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