WEE1

Gene Symbol	WEE1
Entrez Gene	7465
Alt Symbol	WEE1A, WEE1hu
Species	Human
Gene Type	protein-coding
Description	WEE1 G2 checkpoint kinase
Other Description	WEE1 homolog\|WEE1+ homolog\|wee1-like protein kinase\|wee1A kinase
Swissprots	B3KVE1 P30291 D3DQV0
Accessions	CAC14173 EAW68586 EAW68587 EAW68588 P30291 AK122837 BAG53753 BC051831 AAH51831 BC070052 AAH70052 BQ024511 BX641032 CAE46020 EU832325 ACE87582 EU832410 ACE86895 U10564 AAB60401 X62048 CAA43979 XM_005253118 XP_005253175 XM_005253119 XP_005253176 NM_001143976 NP_001137448 NM_003390 NP_003381
Function	Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
Subcellular Location	Nucleus.
Top Pathways	Cell cycle

Category	Cell Line
Species	Human

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