PATL1

Gene Symbol PATL1
Entrez Gene 219988
Alt Symbol Pat1b, hPat1b
Species Human
Gene Type protein-coding
Description protein associated with topoisomerase II homolog 1 (yeast)
Other Description PAT1-like protein 1|protein PAT1 homolog 1|protein PAT1 homolog b
Swissprots Q2TA86 Q6P166 B3KXT9 Q86TB9 Q8N9M6 Q8NI63
Accessions EAW73850 EAW73851 Q86TB9 AB065087 BAB93524 AK094193 BAC04305 AK127649 BAG54542 AK127943 BAG54601 AK293213 BAH11469 AL831992 CAD89916 AM392959 CAL37837 BC023255 BC048309 BC065264 AAH65264 BC109038 AAI09039 BC109039 AAI09040 BC111047 AAI11048 DC409866 XM_005273833 XP_005273890 XM_005273834 XP_005273891 XM_005273835 XP_005273892 XM_011544811 XP_011543113 NM_152716 NP_689929
Function RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV). {ECO:0000269|PubMed:17936923, ECO:0000269|PubMed:19628699, ECO:0000269|PubMed:20543818, ECO:0000269|PubMed:20584987, ECO:0000269|PubMed:20852261}.
Subcellular Location Cytoplasm, P-body. Nucleus. Nucleus, PML body. Nucleus speckle. Note=Predominantly cytoplasmic. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Enriched in splicing speckles. Localization to nuclear foci and speckles requires active transcription. Excluded from the nucleolus.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:17936923}.
Top Pathways RNA degradation

PATL1 Antibody Blocking Peptide - LS-E10324 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

PATL1-Antibody-C-term-Blocking-Peptide - BP9796b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

PATL1 fusion protein - Ag16247 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PGEX-4T
Species Human

PATL1 fusion protein - Ag16315 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

Recombinant Human PATL1, GST-tagged - PATL1-1538H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Human Protein PAT1 homolog 1(PATL1) - CSB-YP801224HU CSB-EP801224HU CSB-BP801224HU CSB-MP801224HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

PATL1 Recombinant Protein Antigen - NBP1-93808PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

PATL1 Peptide, Human - M34GP11336H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Protein PAT1 homolog 1 (PATL1), Recombinant Protein - MBS1320758 from MyBioSource

Category Protein
Prices $1,585.00, $1,585.00, $1,815.00, $1,815.00, $2,740.00, $2,740.00, $3,180.00, $3,180.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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