| Gene Symbol | CREB3 |
|---|---|
| Entrez Gene | 10488 |
| Alt Symbol | LUMAN, LZIP, sLZIP |
| Species | Human |
| Gene Type | protein-coding |
| Description | cAMP responsive element binding protein 3 |
| Other Description | CREB-3|basic leucine zipper protein|cAMP-responsive element-binding protein 3|cyclic AMP response element (CRE)-binding protein/activating transcription factor 1|cyclic AMP-responsive element-binding protein 3|leucin zipper proitein|leucine zipper protein|small leucine zipper protein|transcription factor LZIP-alpha |
| Swissprots | Q9H2W3 Q9UE77 Q5TCV1 O14671 Q96GK8 O43889 D0PTW6 O14919 |
| Accessions | AAD09210 AAG43527 EAW58350 EAW58351 O43889 AF009368 AAB69652 AF029674 AAB84166 AF211848 AAG43528 AK299781 BAG61663 AK313635 BAG36394 BC009402 AAH09402 BC010158 AAH10158 BG701230 BQ014045 EU446868 ABZ92397 FJ263669 ACN32251 U88528 AAC04325 NM_006368 NP_006359 |
| Function | Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response (UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Isoform 2 plays a role in the unfolded protein response (UPR). Isoform 2 acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration. Isoform 2 may play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HSV) core protein. Isoform 2 represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestring host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection. Isoform 3 functions as a negative transcripti |
| Subcellular Location | Processed cyclic AMP-responsive element- binding protein 3: Nucleus. Note=Upon RIP activation the transcriptional active processed cyclic AMP-responsive element- binding protein 3 form translocates into the nucleus. Detected in the nucleus upon dendritic cell maturation and RIP activation. Colocalizes with CREBRF in nuclear foci. Colocalizes with CREBZF in promyelocytic leukemia protein nuclear bodies (PML-NB). |
| Tissue Specificity | Expressed in dendritic cells (DC). Weakly expressed in monocytes (at protein level). Ubiquitous. {ECO:0000269|PubMed:10675342, ECO:0000269|PubMed:19779205, ECO:0000269|PubMed:20546900, ECO:0000269|PubMed:9271389, ECO:0000269|PubMed:9389645}. |
| Top Pathways | cGMP-PKG signaling pathway, Huntington's disease, Glucagon signaling pathway, Prostate cancer, cAMP signaling pathway |