| Gene Symbol |
CAPN2
|
| Entrez Gene |
281662
|
| Alt Symbol |
-
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
calpain 2, (m/II) large subunit
|
| Other Description |
CANP 2|M-calpain|calcium-activated neutral proteinase 2|calpain M-type|calpain, large polypeptide L2|calpain-2 catalytic subunit|calpain-2 large subunit|millimolar-calpain
|
| Swissprots |
Q27971 A4IFD3
|
| Accessions |
DAA21366 Q27971 BC134526 AAI34527 U07850 AAA18455 NM_001103086 NP_001096556
|
| Function |
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocates to the plasma membrane upon Ca(2+) binding. {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
Apoptosis, Focal adhesion, Alzheimer's disease, Protein processing in endoplasmic reticulum
|