| Gene Symbol |
LIN54
|
| Entrez Gene |
132660
|
| Alt Symbol |
CXCDC1, JC8.6, MIP120
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lin-54 DREAM MuvB core complex component
|
| Other Description |
CXC domain-containing protein 1|lin-54 homolog|protein lin-54 homolog
|
| Swissprots |
Q6N071 Q6MZP7 Q76B60 Q32M69 Q32M68
|
| Accessions |
EAX05917 EAX05918 EAX05919 EAX05920 Q6MZP7 AB111889 BAC98377 AI208524 AK292769 BAF85458 AK294256 BAG57551 AK299787 BAG61668 BC109277 AAI09278 BC109278 AAI09279 BX108765 BX537919 CAD97902 BX640657 CAE45799 BX640966 CAE45981 CK819664 CX871759 DC335927 DC407712 EU831591 ACE87191 EU831592 ACE87192 EU831676 ACE86510 EU831677 ACE86511 XM_005262750 XP_005262807 XM_006714081 XP_006714144 NM_001115007 NP_001108479 NM_001115008 NP_001108480 NM_001288996 NP_001275925 NM_001288997 NP_001275926 NM_194282 NP_919258 NR_110253 NR_110254
|
| Function |
Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|