Gene Symbol | Tnf |
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Entrez Gene | 21926 |
Alt Symbol | DIF, TNF-a, TNF-alpha, TNFSF2, TNFalpha, Tnfa, Tnfsf1a |
Species | Mouse |
Gene Type | protein-coding |
Description | tumor necrosis factor |
Other Description | cachectin|tumor necrosis factor ligand superfamily member 2|tumor necrosis factor-alpha |
Swissprots | Q91VF3 Q62326 O35853 P06804 |
Accessions | AAA18594 AAA40459 AAA40462 AAB65593 AAC82484 BAA19512 BAA19513 BAB68748 BAB68750 BAB68751 BAB68752 BAB68753 BAB68754 BAB68755 BAB68756 BAB78397 BAF02298 BAF02299 BAF02300 CAA68530 EDL26631 EDL26632 P06804 AK153319 BAE31899 AK153800 BAE32187 AK154223 BAE32445 AK155964 BAE33525 AY423855 AAR00346 BC117057 AAI17058 BC137720 AAI37721 BY167004 M11731 AAA40458 M13049 AAA40457 X02611 CAA26457 NM_001278601 NP_001265530 NM_013693 NP_038721 |
Function | Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. |
Subcellular Location | C-domain 2: Secreted {ECO:0000250}. |
Top Pathways | T cell receptor signaling pathway, Allograft rejection, Systemic lupus erythematosus, HTLV-I infection, Influenza A |
TNFα CRISPR/Cas9 KO Plasmid (m) - sc-423433 from Santa Cruz Biotechnology
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TNFα HDR Plasmid (m) - sc-423433-HDR from Santa Cruz Biotechnology
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TNFα Double Nickase Plasmid (m) - sc-423433-NIC from Santa Cruz Biotechnology
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TNFα Double Nickase Plasmid (m2) - sc-423433-NIC-2 from Santa Cruz Biotechnology
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TNFα CRISPR Activation Plasmid (m) - sc-423433-ACT from Santa Cruz Biotechnology
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TNFα CRISPR Activation Plasmid (m2) - sc-423433-ACT-2 from Santa Cruz Biotechnology
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TNFα Lentiviral Activation Particles (m) - sc-423433-LAC from Santa Cruz Biotechnology
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TNFα Lentiviral Activation Particles (m2) - sc-423433-LAC-2 from Santa Cruz Biotechnology
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TNFα siRNA (m) - sc-37217 from Santa Cruz Biotechnology
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TNFα shRNA Plasmid (m) - sc-37217-SH from Santa Cruz Biotechnology
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TNFα shRNA (m) Lentiviral Particles - sc-37217-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU012051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN43215 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND43215 from Sigma-Aldrich
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TNF siRNA (Mouse) - CRM4175 from Cohesion Biosciences
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TNF - MBS8201527 from MyBioSource
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shRNA set against Mouse TNF (NM_013693.2) - SHH431740 from Creative biogene
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shRNA set against Mouse Tnf(NM_013693.2) - SHL084132 from Creative biogene
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Mouse TNF siRNA - orb283651 from Biorbyt
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TNF shRNA Plasmid (Mouse) - CHM4175 from Cohesion Biosciences
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TNF miRNA 3'UTR clone - MiUTR1M-11981 from Creative biogene
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