FZD7

Gene Symbol	FZD7
Entrez Gene	8324
Alt Symbol	FzE3
Species	Human
Gene Type	protein-coding
Description	frizzled class receptor 7
Other Description	Frizzled, drosophila, homolog of, 7|frizzled 7, seven transmembrane spanning receptor|frizzled family receptor 7|frizzled homolog 7|frizzled-7|fz-7|hFz7
Swissprots	O94816 Q53S59 Q96B74 O75084
Accessions	AAX93250 EAW70298 O75084 AB010881 BAA32424 AB017365 BAA34668 BC015915 AAH15915 JF432234 ADZ15451 NM_003507 NP_003498
Function	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Subcellular Location	Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue Specificity	High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas.
Top Pathways	Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Frizzled 7 full length protein - ab132107 from Abcam Category Protein Source Wheat germ Species Human

Human Frizzled 7 peptide - ab64635 from Abcam Category Peptide

Human Frizzled 7 protein fragment - ab112378 from Abcam Category Protein Source Wheat germ Species Human

Human Frizzled 7 protein fragment - ab151825 from Abcam Category Protein Source HEK 293 cells Species Human

Human Frizzled 7 protein fragment - ab191958 from Abcam Category Protein Source HEK 293 cells Species Human

FZD7 / Frizzled 7 Antibody Blocking Peptide - LS-E5501 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FZD7 / Frizzled 7 Antibody Blocking Peptide - LS-E29007 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

FZD7 / Frizzled 7 Antibody Blocking Peptide - LS-E29006 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

FZD7 / Frizzled 7 Antibody Blocking Peptide - LS-E29005 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

FZD7 / Frizzled 7 Antibody Blocking Peptide - LS-E26624 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Frizzled-7 Protein - H00008324-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

FZD7-Antibody-Center-Blocking-Peptide - BP18021c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Frizzled 7 blocking peptide - GTX88831-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse

Recombinant Human Frizzled-7 Fc Chimera, CF - 6178-FZ-050 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived

FZD7 Blocking Peptide - 33R-7010 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Frizzled 7 Peptide - AC21-1460-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

FZD7 / Frizzled-7 - H00008324-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

FZD7 / Frizzled-7 - H00008324-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

FZD7 / Frizzled-7 - H00008324-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Species Human

FZD7 / Frizzled-7 - H00008324-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

FZD7 / Frizzled-7 - H00008324-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Frizzled-7, Human, Recombinant - 19-C413 from ARP American Research Products Category Protein Prices $109.00 Sizes 10 µg Source HEK293 Species Human

Frizzled 7 Peptide - 45-635P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

Frizzled 7 Recombinant Protein - 96-335 from ProSci Category Protein Prices $425.00 Sizes 100 µg Source HEK293 cells Species Human

FZD7 fusion protein - ag9446 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Search more