TGFBR1

Gene Symbol TGFBR1
Entrez Gene 7046
Alt Symbol AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, TGFR-1, tbetaR-I
Species Human
Gene Type protein-coding
Description transforming growth factor, beta receptor 1
Other Description TGF-beta receptor type-1|activin A receptor type II-like kinase, 53kDa|activin A receptor type II-like protein kinase of 53kD|activin receptor-like kinase 5|serine/threonine-protein kinase receptor R4|transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD)|transforming growth factor-beta receptor type I
Swissprots Q6IR47 P36897 Q706C1 Q706C0
Accessions AAC08998 AAD02042 AAR32097 ABD46753 ACZ58375 CAZ91468 EAW58905 EAW58906 P36897 AJ420419 AJ619019 CAF02096 AJ619020 CAF02097 AK002171 AK129793 AK302059 BAG63449 AK302234 BAG63588 AL117597 BC038347 BC056247 BC071181 AAH71181 BX648917 EF142853 ABO93068 EF142854 ABO93069 L11695 AAA16073 XM_005252150 XP_005252207 XM_011518948 XP_011517250 XM_011518949 XP_011517251 XM_011518950 XP_011517252 NM_001130916 NP_001124388 NM_001306210 NP_001293139 NM_004612 NP_004603
Function Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of
Subcellular Location Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction.
Tissue Specificity Found in all tissues examined, most abundant in placenta and least abundant in brain and heart.
Top Pathways TGF-beta signaling pathway, Hippo signaling pathway, Adherens junction, Chronic myeloid leukemia, Colorectal cancer

TGF-β Receptor I Antibody - 3712 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Mv 1 Lu and Hep G2 cells using TGF-β Receptor I Antibody.

TGFβ RI (H-100) - sc-9048 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TGFβ RI (H-100): sc-9048. Immunofluorescence staining of normal mouse intestine frozen section showing membrane staining.

TGFβ RI (V-22) - sc-398 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TGFβ RI (V-22): sc-398. Immunoperoxidase staining of formalin-fixed, paraffin-embedded wounded ovine skin one day following excisional injury. Note cytoplasmic and membrane staining. Kindly provided by Leslie Gold.

TGFβ RI (G-16) - sc-33933 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TGFβ RI (R-20) - sc-399 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TGFβ RI (R-20): sc-399. Western blot analysis of TGFβ RI expression in human platelet extract.

Anti-TGF beta Receptor I (phospho S165) antibody - ab112095 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab112095, at a 1/100 dilution, staining TGF beta Receptor I in HeLa cells by Immunofluorescence, in the absence (left) and presence (right) of the phosphopeptide.

Anti-TGF beta Receptor I antibody - ab135814 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-TGF beta Receptor I antibody (ab135814) at 1/100 dilution + Jurkat cell line lysates at 35 µg

Anti-TGF beta Receptor I antibody [8A11] - ab49575 from Abcam

Host Mouse
Clonality Monoclonal
Clone 8A11
Human colon, ulcerative colitis: IHC-P staining for transforming growth factor beta receptor (type 1) using ab49575. Membrane staining of a proportion of epithelial cells and lymphocytes.

Anti-TGF beta Receptor I antibody [MM0016-7B09] - ab51871 from Abcam

Prices $376.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone MM0016-7B09
ab51871 at 1/200 dilution staining TGF beta Receptor I in human placental tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections).

Anti-TGFBR1 / ALK5 Antibody - LS-C334762 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of Jurkat cell line, using TGFBR1 antibody.

Anti-TGFBR1 / ALK5 Antibody (aa158-179) IHC-plus™ - LS-B3261 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TGFBR1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3261 concentration 15 ug/ml.

Anti-TGFBR1 / ALK5 Antibody (aa162-403) - LS-C314493 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant TGFBR1 / ALK5.

Anti-TGFBR1 / ALK5 Antibody (aa50-63) IHC-plus™ - LS-B9436 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-TGFBR1 / ALK5 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-TGFBR1 / ALK5 Antibody (N-Terminus) - LS-C26376 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TGFBR1 / ALK5 Antibody - LS-C89656 from LifeSpan Bioscience

Prices $475.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal

Anti-TGFBR1 / ALK5 Antibody (Biotin) - LS-C132633 from LifeSpan Bioscience

Prices $650.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-TGFBR1 / ALK5 Antibody (Extracellular Domain, clone 7B09) - LS-C194780 from LifeSpan Bioscience

Prices $830.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 7B09

Anti-TGFBR1 / ALK5 Antibody (Extracellular Domain, clone 3A11) - LS-C194781 from LifeSpan Bioscience

Prices $830.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 3A11

Anti-TGFBR1 / ALK5 Antibody (aa158-179) IHC-plus™ - LS-B1267 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TGFBR1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1267 concentration 10 ug/ml.

Anti-TGFBR1 / ALK5 Antibody (aa112-161) - LS-C200779 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HeLa cells using TGF beta Receptor I antibody.

Anti-TGFBR1 / ALK5 Antibody (aa141-169, AP) - LS-C271380 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TGFBR1 / ALK5 Antibody (aa131-180) - LS-C117992 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of HeLa cells, using TGF beta Receptor I (Ab-165) Antibody. The picture on the right is treated with the synthesized peptide.

Anti-TGFBR1 / ALK5 Antibody (aa141-169, APC) - LS-C271382 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TGFBR1 / ALK5 Antibody (aa141-169, Biotin) - LS-C271383 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TGFBR1 / ALK5 Antibody (aa134-163) - LS-C97221 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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