AURKC
| Gene Symbol | AURKC |
|---|---|
| Entrez Gene | 6795 |
| Alt Symbol | AIE2, AIK3, ARK3, AurC, SPGF5, STK13, aurora-C |
| Species | Human |
| Gene Type | protein-coding |
| Description | aurora kinase C |
| Other Description | ARK-3|aurora 3|aurora-related kinase 3|aurora/IPL1-related kinase 3|aurora/IPL1/EG2 protein 2|serine/threonine kinase 13 (aurora/IPL1-like)|serine/threonine-protein kinase 13|serine/threonine-protein kinase aurora-C |
| Swissprots | Q9UPK5 Q6DLZ0 O75442 Q9UQB9 Q6AZY8 O60681 |
| Accessions | EAW72485 EAW72486 Q9UQB9 AB017332 BAA76292 AF054621 AAC25955 AF059681 AAC77369 AK301886 BAG63318 AY661554 AAT64422 AY714054 AAU04399 BC075064 AAH75064 BX092186 EU668345 ACF94498 XR_430209 NM_001015878 NP_001015878 NM_001015879 NP_001015879 NM_003160 NP_003151 |
| Function | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. {ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:15499654, ECO:0000269|PubMed:15670791, ECO:0000269|PubMed:15938719, ECO:0000269|PubMed:21493633, ECO:0000269|PubMed:21531210}. |
| Subcellular Location | Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis. |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase. {ECO:0000269|PubMed:15670791}. |
ARK-3 CRISPR/Cas9 KO Plasmid (h) - sc-408004 from Santa Cruz Biotechnology
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ARK-3 HDR Plasmid (h) - sc-408004-HDR from Santa Cruz Biotechnology
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ARK-3 Double Nickase Plasmid (h) - sc-408004-NIC from Santa Cruz Biotechnology
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ARK-3 Double Nickase Plasmid (h2) - sc-408004-NIC-2 from Santa Cruz Biotechnology
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ARK-3 CRISPR Activation Plasmid (h) - sc-408004-ACT from Santa Cruz Biotechnology
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ARK-3 CRISPR Activation Plasmid (h2) - sc-408004-ACT-2 from Santa Cruz Biotechnology
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ARK-3 Lentiviral Activation Particles (h) - sc-408004-LAC from Santa Cruz Biotechnology
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ARK-3 Lentiviral Activation Particles (h2) - sc-408004-LAC-2 from Santa Cruz Biotechnology
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ARK-3 siRNA (h) - sc-60202 from Santa Cruz Biotechnology
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ARK-3 shRNA Plasmid (h) - sc-60202-SH from Santa Cruz Biotechnology
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ARK-3 shRNA (h) Lentiviral Particles - sc-60202-V from Santa Cruz Biotechnology
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Aurora C RNAi - H00006795-R06 from Novus Biologicals
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Aurora C RNAi - H00006795-R04 from Novus Biologicals
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MISSION® siRNA - SIHK0146 from Sigma-Aldrich
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MISSION® siRNA - SIHK0148 from Sigma-Aldrich
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MISSION® siRNA - SIHK0147 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3774 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3774 from Sigma-Aldrich
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AURKC siRNA (Human) - CRH4650 from Cohesion Biosciences
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Aurora C RNAi - H00006795-R05 from Novus Biologicals
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AURKC - MBS8223497 from MyBioSource
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shRNA set against Human AURKC (NM_003160.2) - SHH243758 from Creative biogene
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shRNA set against Human AURKC(NM_001015879.1) - SHG086265 from Creative biogene
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shRNA set against Human AURKC(NM_003160.2) - SHG086491 from Creative biogene
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shRNA set against Human AURKC(NM_001015878.1) - SHG086545 from Creative biogene
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