Gene Symbol | ELOVL2 |
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Entrez Gene | 54898 |
Alt Symbol | SSC2 |
Species | Human |
Gene Type | protein-coding |
Description | ELOVL fatty acid elongase 2 |
Other Description | 3-keto acyl-CoA synthase ELOVL2|ELOVL FA elongase 2|elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2|elongation of very long chain fatty acids protein 2|very-long-chain 3-oxoacyl-CoA synthase 2 |
Swissprots | Q6P9E1 Q86W94 Q9NXB9 |
Accessions | EAW55290 EAW55291 EAW55292 Q9NXB9 AJ420504 AK000341 BAA91096 AL080199 BC050278 AAH50278 BC060809 AAH60809 HQ448547 ADQ33026 XM_011514716 XP_011513018 XM_011514717 XP_011513019 NM_017770 NP_060240 |
Function | Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n- 6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:12371743, ECO:0000269|PubMed:20937905}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:20937905}; Multi-pass membrane protein {ECO:0000255}. |
Tissue Specificity | Liver and testis. {ECO:0000269|PubMed:20937905}. |
Top Pathways | Fatty acid elongation, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism |
Elongation of very long chain fatty acids protein 2 (ELOVL2), Human, ELISA Kit - CSB-EL007620HU from ARP American Research Products
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elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast) -like 2, ELISA Kit - MBS906105 from MyBioSource
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Human Elongation of very long chain fatty acids protein 2(ELOVL2) ELISA kit - CSB-EL007620HU from Cusabio
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Human ELOVL2 ELISA Kit - E012947 from Biobool
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ELOVL2 ELISA Kit (Human) (OKCA01220) - OKCA01220 from Aviva Systems Biology
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