| Gene Symbol |
SE
|
| Entrez Gene |
817252
|
| Alt Symbol |
SERRATE, T20P8.15, T20P8_15
|
| Species |
Arabidopsis thaliana
|
| Gene Type |
protein-coding
|
| Description |
serrate RNA effector molecule
|
| Other Description |
-
|
| Swissprots |
Q9ZVD0 Q93W84
|
| Accessions |
AAC77868 AEC07936 Q9ZVD0 AF311221 AAK63206 AF428305 AAL16137 AY039915 AAK64019 AY142569 AAN13138 AY143937 AAN28876 NM_128268 NP_565635
|
| Function |
Acts as a mediator between the cap-binding complex (CBC) and both the pre-mRNA splicing and primary microRNAs (miRNAs) processing machinery. Required for proper processing of primary miRNAs to miRNAs, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Does not participate in sense post- transcriptional gene silencing. Acts as a regulator of meristem activity and adaxial leaf fate via the miRNA gene-silencing pathway by regulating the expression of PHB and by limiting the competence of shoot tissue to respond to KNOX expression. Its function is however not limited to miRNA-mediated repression of leaf polarity genes, but rather acts as a general regulator of primary microRNAs processing. Also critical for the accumulation of the trans-acting small interfering RNA (ta-siRNA). Required for pre-mRNA splicing. {ECO:0000269|PubMed:16222298, ECO:0000269|PubMed:16889646, ECO:0000269|PubMed:16977334, ECO:0000269|PubMed:18550839, ECO:0000269|PubMed:18632569}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:16889646, ECO:0000269|PubMed:17442570, ECO:0000269|PubMed:17675322, ECO:0000269|PubMed:19245862}. Note=Localizes to nuclear dicing body (also named D body), a nuclear body distributed throughout the nucleoplasm involved in miRNA processing.
|
| Tissue Specificity |
Expressed in shoot meristems and in emerging organ primordia throughout development. {ECO:0000269|PubMed:11402159}.
|
