| Gene Symbol |
ZFP36
|
| Entrez Gene |
282127
|
| Alt Symbol |
-
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
ZFP36 ring finger protein
|
| Other Description |
TIS11|TTP|tristetraprolin|tristetraproline|zfp-36|zinc finger protein 36 homolog|zinc finger protein 36, C3H type, homolog|zinc finger protein homologous to Zfp-36 in mouse
|
| Swissprots |
P53781
|
| Accessions |
AAB05819 DAA19897 P53781 BC120043 AAI20044 NM_174493 NP_776918
|
| Function |
mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the post- transcriptional regulation of tumor necrosis factor (TNF). Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF) (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Localizes to stress granules upon energy starvation. phosphorylation by MAPKAPK2 promotes exclusion from stress granules (By similarity). {ECO:0000250}.
|
| Top Pathways |
HTLV-I infection
|