IL6ST

Gene Symbol	IL6ST
Entrez Gene	3572
Alt Symbol	CD130, CDW130, GP130, IL-6RB
Species	Human
Gene Type	protein-coding
Description	interleukin 6 signal transducer
Other Description	CD130 antigen|IL-6 receptor subunit beta|IL-6R subunit beta|gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form|gp130, oncostatin M receptor|interleukin receptor beta chain|interleukin-6 receptor subunit beta|membrane glycoprotein 130|membrane glycoprotein gp130|oncostatin-M receptor subunit alpha
Swissprots	Q9UQ41 Q5FC04 P40189 A0N0L4
Accessions	ABK41905 EAW54936 EAW54937 EAW54938 P40189 AB015706 BAA78112 AB074172 AB102799 BAD89390 AB102800 BAD89391 AB102801 BAD89392 AB102802 BAD89393 AB102803 BAD89394 AB102804 BAD89395 AL049265 AW015107 BC071555 BC117402 AAI17403 BC117404 AAI17405 BC143842 BQ013034 DA863210 DA877322 HQ258523 ADR83277 HQ628629 AER93379 HQ628630 AER93380 M57230 AAA59155 S80479 AAB35921 U58146 AAB63010 XM_011543376 XP_011541678 XM_011543377 XP_011541679 NM_001190981 NP_001177910 NM_002184 NP_002175 NM_175767 NP_786943 NR_120480
Function	Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events. {ECO:0000250}.
Subcellular Location	Isoform 1: Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.
Top Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Viral carcinogenesis, Signaling pathways regulating pluripotency of stem cells

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CD130 (GP130) Human ELISA Kit - ab46135 from Abcam Category ELISA Kit Prices $489.00, $734.00 Sizes 1 x 96 tests, 2 x 96 tests Sensitivity < 15 pg/ml Range 56.25 pg/ml - 1800 pg/ml

Human IL6ST / CD130 / gp130 ELISA Kit (Sandwich ELISA) - LS-F2440 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 10 pg/ml Range 40.96-4000 pg/ml

Mouse IL6ST / CD130 / gp130 ELISA Kit (Sandwich ELISA) - LS-F2588 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 125 pg/ml Range 40.96-4000 pg/ml

Human IL6ST / CD130 / gp130 ELISA Kit (Sandwich ELISA) - LS-F4016 from LifeSpan Bioscience Category ELISA Kit Prices $500.00 Sizes 1 plate Sensitivity 0.115 ng/ml Range 40.96-4000 pg/ml

Mouse IL6ST / CD130 / gp130 ELISA Kit (Sandwich ELISA) - LS-F4017 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 48 pg/ml Range 40.96-4000 pg/ml

Rat IL6ST / CD130 / gp130 ELISA Kit (Sandwich ELISA) - LS-F5472 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.244 ng/ml Range 40.96-4000 pg/ml

Mouse IL6ST / CD130 / gp130 ELISA Kit (Sandwich ELISA) - LS-F246 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 40.96 pg/ml Range 40.96-4000 pg/ml

Human IL6ST / CD130 / gp130 ELISA Kit (Sandwich ELISA) - LS-F10267 from LifeSpan Bioscience Category ELISA Kit Prices $630.00 Sizes 1 plate Sensitivity 0.516 ng/ml Range 40.96-4000 pg/ml

Human IL6ST / CD130 / gp130 ELISA Kit (Sandwich ELISA) - LS-F11805 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 0.156 Range 40.96-4000 pg/ml

Rat IL6ST / CD130 / gp130 ELISA Kit (Sandwich ELISA) - LS-F11806 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 40.96-4000 pg/ml

Human sgp130 ELISA Kit - RAB0315 from Sigma-Aldrich Category ELISA Kit Prices $423.50 Sizes 1 kt

Human gp130 Luminex Performance Assay - LBA228 from R&D Systems

Human Soluble gp130 Quantikine ELISA Kit - DGP00 from R&D Systems Category ELISA Kit Prices $509.00 Sizes 1 kit Sensitivity 0.08 ng/mL Range 0.1 - 8 ng/mL (Cell Culture Supernates), 0.3 - 16 ng/mL (Serum, EDTA Plasma, Heparin Plasma, Citrate Plasma)

Human sgp130 DuoSet ELISA - DY228 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 156.00 - 10,000 pg/mL

Mouse gp130 DuoSet ELISA - DY468 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 125.00 - 8,000 pg/mL

Human Phospho-gp130 DuoSet IC ELISA, 2 Plate - DYC3407-2 from R&D Systems Category ELISA Kit Prices $329.00 Sizes 1 kit (for 2 Plates)

Human Total gp130 DuoSet IC ELISA, 2 Plate - DYC228-2 from R&D Systems Category ELISA Kit Prices $329.00 Sizes 1 kit (for 2 Plates) Range 156.00 - 10,000 pg/mL

Human CD130 ELISA Kit - abx056062 from Abbexa Category ELISA Kit

Glucoprotein 130 (gp130), Human, ELISA Kit - SEA046Hu from ARP American Research Products Category ELISA Kit Prices $498.00 Sizes 96 t Sensitivity 0.115ng/mL Range 0.312-20ng/mL

Glucoprotein 130, gp130/CD130, Human, ELISA Kit - YHB1338Hu from ARP American Research Products Category ELISA Kit

Interleukin-6 receptor subunit beta, IL6ST, Human, ELISA Kit - E0046h from ARP American Research Products Category ELISA Kit Prices $476.00 Sizes 96 t Range 0.156-10 ng/mL

soluble Glucoprotein 130, sgp130, Human, ELISA Kit - E-EL-H0082 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.15 Range 0.25-16ng/mL

IL6ST (Human) ELISA Kit - KA2143 from Acris Antibodies Category ELISA Kit Prices $650.00 Sizes 1 kit

Human sgp130 ELISA - ELH-sgp130 from RayBiotech Category ELISA Kit Prices $390.00, $702.00, $1,561.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 4 pg/ml Range 4 pg/ml- 6000 pg/ml

Glucoprotein 130, ELISA Kit - MBS736512 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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