IL6ST

Gene Symbol	IL6ST
Entrez Gene	3572
Alt Symbol	CD130, CDW130, GP130, IL-6RB
Species	Human
Gene Type	protein-coding
Description	interleukin 6 signal transducer
Other Description	CD130 antigen|IL-6 receptor subunit beta|IL-6R subunit beta|gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form|gp130, oncostatin M receptor|interleukin receptor beta chain|interleukin-6 receptor subunit beta|membrane glycoprotein 130|membrane glycoprotein gp130|oncostatin-M receptor subunit alpha
Swissprots	Q9UQ41 Q5FC04 P40189 A0N0L4
Accessions	ABK41905 EAW54936 EAW54937 EAW54938 P40189 AB015706 BAA78112 AB074172 AB102799 BAD89390 AB102800 BAD89391 AB102801 BAD89392 AB102802 BAD89393 AB102803 BAD89394 AB102804 BAD89395 AL049265 AW015107 BC071555 BC117402 AAI17403 BC117404 AAI17405 BC143842 BQ013034 DA863210 DA877322 HQ258523 ADR83277 HQ628629 AER93379 HQ628630 AER93380 M57230 AAA59155 S80479 AAB35921 U58146 AAB63010 XM_011543376 XP_011541678 XM_011543377 XP_011541679 NM_001190981 NP_001177910 NM_002184 NP_002175 NM_175767 NP_786943 NR_120480
Function	Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events. {ECO:0000250}.
Subcellular Location	Isoform 1: Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.
Top Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Viral carcinogenesis, Signaling pathways regulating pluripotency of stem cells

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CD130 (gp130) protein fragment - ab114303 from Abcam Category Protein Prices $420.00 Sizes 10 µg Source Wheat germ Species Human

Mouse CD130 (gp130) protein fragment - ab200504 from Abcam Category Protein Source HEK 293 cells Species Mouse

IL6ST / CD130 / gp130 Antibody Blocking Peptide - LS-E750 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IL6ST / CD130 / gp130 Antibody Blocking Peptide - LS-E7450 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IL6ST / CD130 / gp130 Antibody Blocking Peptide - LS-E23068 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

gp130/CD130 Partial Recombinant Protein - H00003572-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

gp130/CD130 Recombinant Protein - H00003572-G01-10ug from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

CD130-Antibody-C-term-Blocking-peptide - BP11107b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-IL6STY905-Antibody-Blocking-peptide - BP3663a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Recombinant Human Soluble gp130 - 228-GP-010 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Leu24-Glu619 (Glu619Asp)

Recombinant Human Soluble gp130 - 228-GP-050 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Leu24-Glu619 (Glu619Asp)

Recombinant Human Soluble gp130, CF - 228-GP-010/CF from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Leu24-Glu619 (Glu619Asp)

Recombinant Human Soluble gp130, CF - 228-GP-050/CF from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Leu24-Glu619 (Glu619Asp)

Recombinant Human gp130 Fc Chimera, CF - 671-GP-100 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Mouse gp130 Fc Chimera, CF - 468-MG-100 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Cynomolgus IL6ST protein - orb139210 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 100 μg, 200 μg Source Human Cells

Human IL6ST (Fc Tag) protein - orb232252 from Biorbyt Category Protein Prices $400.00, $978.00 Sizes 10 μg, 50 μg Species Human

Cynomolgus IL6ST protein (His Tag) - orb139211 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 100 μg, 200 μg Source Human Cells

Human IL6ST Fc His tag protein - orb83289 from Biorbyt Category Protein Prices $323.00, $527.00 Sizes 10 μg, 20 μg Source Human Species Human

Mouse IL6ST His tag protein - orb84110 from Biorbyt Category Protein Prices $510.00, $748.00 Sizes 100 μg, 200 μg Source Mouse Species Human

Human IL6ST protein - orb139212 from Biorbyt Category Protein Prices $510.00, $748.00 Sizes 100 μg, 200 μg Source Human Cells Species Human

Human Glycoprotein 130 Protein - abx066882 from Abbexa Category Protein Source E.coli Species Human

Human Glycoprotein 130 Protein - abx066881 from Abbexa Category Protein Source E.coli Species Human

CD130 / IL6ST - H00003572-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD130 / IL6ST - H00003572-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

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